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GSTM5 glutathione S-transferase mu 5 [ Homo sapiens (human) ]

Gene ID: 2949, updated on 2-Nov-2024

Summary

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Official Symbol
GSTM5provided by HGNC
Official Full Name
glutathione S-transferase mu 5provided by HGNC
Primary source
HGNC:HGNC:4637
See related
Ensembl:ENSG00000134201 MIM:138385; AllianceGenome:HGNC:4637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTM5; GSTM5-5
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]
Expression
Biased expression in ovary (RPKM 81.4), gall bladder (RPKM 13.9) and 9 other tissues See more
Orthologs
all
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Genomic context

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See GSTM5 in Genome Data Viewer
Location:
1p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109711751..109718268)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109721793..109728310)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110254873..110260890)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1450 Neighboring gene glutathione S-transferase mu 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1451 Neighboring gene glutathione S-transferase mu 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1158 Neighboring gene glutathione S-transferase mu 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:110293035-110294234 Neighboring gene EPS8 signaling adaptor L3 Neighboring gene uncharacterized LOC124904258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110303188-110303917

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer. Jou YC, et al. Int J Mol Sci, 2021 Mar 17. PMID 33802702, Free PMC Article
  2. Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis. Hao X, et al. BMC Cancer, 2022 Jun 21. PMID 35729618, Free PMC Article
  3. GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration. Hunter AA 3rd, et al. Curr Eye Res, 2016. PMID 25897651, Free PMC Article
  4. A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. Takahashi Y, et al. J Biol Chem, 1993 Apr 25. PMID 8473333
  5. Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Rowe JD, et al. Biochem J, 1997 Jul 15. PMID 9230131, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.
    Title: Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.
  2. Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.
    Title: Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.
  3. Genomic polymorphisms of GSTM1 and GSTM5 do not significantly affect the peripheral blood leukocyte mRNA levels.
    Title: GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.
  4. The evidence presented suggests that GSTM1 and GSTM5 undergo epigenetic repression in AMD RPE/choroid, which may increase susceptibility to oxidative stress in AMD retinas.
    Title: DNA methylation is associated with altered gene expression in AMD.
  5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
glutathione S-transferase Mu 5
Names
GST class-mu 5
S-(hydroxyalkyl)glutathione lyase M5
epididymis secretory sperm binding protein
glutathione S-alkyltransferase M5
glutathione S-aralkyltransferase M5
glutathione S-aryltransferase M5
glutathione S-transferase M5
NP_000842.2
XP_005270841.1
XP_005270842.1
XP_054192143.1
XP_054192144.1
XP_054192145.1
XP_054192146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000851.4 → NP_000842.2  glutathione S-transferase Mu 5

    See identical proteins and their annotated locations for NP_000842.2

    Status: REVIEWED

    Source sequence(s)
    AC000032, BC058881, BX281326, DB089682
    Consensus CDS
    CCDS811.1
    UniProtKB/Swiss-Prot
    A8K0V8, P46439, Q6PD78
    UniProtKB/TrEMBL
    A0A3B3IRM5, Q5T8R2
    Related
    ENSP00000256593.3, ENST00000256593.8
    Conserved Domains (2) summary
    cd03209
    Location:92 → 212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109711751..109718268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270784.5 → XP_005270841.1  glutathione S-transferase Mu 5 isoform X1

    See identical proteins and their annotated locations for XP_005270841.1

    UniProtKB/Swiss-Prot
    A8K0V8, P46439, Q6PD78
    UniProtKB/TrEMBL
    A0A3B3IRM5, Q5T8R2
    Related
    ENSP00000496849.1, ENST00000647711.1
    Conserved Domains (2) summary
    cd03209
    Location:92 → 212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. XM_005270785.5 → XP_005270842.1  glutathione S-transferase Mu 5 isoform X2

    Conserved Domains (1) summary
    cl02776
    Location:1 → 108
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109721793..109728310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336168.1 → XP_054192143.1  glutathione S-transferase Mu 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K0V8, P46439, Q6PD78
    UniProtKB/TrEMBL
    Q5T8R2

  2. XM_054336169.1 → XP_054192144.1  glutathione S-transferase Mu 5 isoform X3

    UniProtKB/TrEMBL
    Q5T8R1

  3. XM_054336170.1 → XP_054192145.1  glutathione S-transferase Mu 5 isoform X2

  4. XM_054336171.1 → XP_054192146.1  glutathione S-transferase Mu 5 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46439.3 GenPept UniProtKB/Swiss-Prot:P46439

Gene LinkOut

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