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ORF1ab ORF1a polyprotein;ORF1ab polyprotein [ Human coronavirus NL63 ]

Gene ID: 2943501, updated on 10-Oct-2024

Summary

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Gene symbol
ORF1ab
Gene description
ORF1a polyprotein;ORF1ab polyprotein
Locus tag
HCNV63gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human coronavirus NL63 (strain: Amsterdam I)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Alphacoronavirus; Setracovirus
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Genomic context

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Sequence:
NC_005831.2 (287..20475)

NC_005831.2Genomic Context describing neighboring genes Neighboring gene spike protein Neighboring gene protein 3 Neighboring gene envelope protein Neighboring gene membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_005831.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. Chen Z, et al. J Virol, 2007 Jun. PMID 17392370, Free PMC Article
  2. Identification of a new human coronavirus. van der Hoek L, et al. Nat Med, 2004 Apr. PMID 15034574, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
ORF1a polyprotein;ORF1ab polyprotein
Names
polyprotein pp1a
polyprotein pp1ab
replicase polyprotein 1ab
YP_003766.2
  • translated via -1 ribosomal frameshift; ORF1ab polyprotein is cleaved to yield the RNA-dependent RNA polymerase and other nonstructural proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005831.2 Reference assembly

    Range
    287..20475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003766.2 ORF1ab polyprotein [Human coronavirus NL63]

    See identical proteins and their annotated locations for YP_003766.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6X5, Q6Q1S3
    UniProtKB/TrEMBL
    K4PE35
    Conserved Domains (13) summary
    smart00506
    Location:1265 → 1391
    A1pp; Appr-1"-p processing enzyme
    COG1112
    Location:5293 → 5560
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06471
    Location:5570 → 6153
    NSP11
    pfam06478
    Location:4056 → 4404
    Corona_RPol_N; Coronavirus RPol N-terminus
    pfam08710
    Location:3800 → 3908
    nsp9; nsp9 replicase
    pfam08716
    Location:3522 → 3604
    nsp7; nsp7 replicase
    pfam08717
    Location:3605 → 3799
    nsp8; nsp8 replicase
    pfam09401
    Location:3920 → 4038
    NSP10; RNA synthesis protein NSP10
    cd17934
    Location:5243 → 5414
    DEXXQc_Upf1-like; DEXXQ-box helicase domain of Upf1-like helicase
    pfam05409
    Location:2968 → 3256
    Peptidase_C30; Coronavirus endopeptidase C30
    pfam06460
    Location:6430 → 6729
    NSP13; Coronavirus NSP13
    pfam08715
    Location:1584 → 1877
    Viral_protease; Papain like viral protease
    pfam16348
    Location:2847 → 2938
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus

  2. YP_010229075.1 ORF1a polyprotein [Human coronavirus NL63]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6U6
    Conserved Domains (15) summary
    cd21473
    Location:2470 → 2836
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21558
    Location:3227 → 3521
    alphaCoV-Nsp6; alphacoronavirus non-structural protein 6
    cd21514
    Location:111 → 724
    cv_alpha_Nsp2_HCoV-229E-like; alphacoronavirus non-structural protein 2 (Nsp2), similar to HCoV-229E Nsp2 and related proteins
    cd21557
    Location:1282 → 1406
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21665
    Location:2942 → 3238
    alphaCoV_Nsp5_Mpro; alphacoronavirus non-structural protein 5, also called Main protease (Mpro)
    pfam08715
    Location:1037 → 1213
    Viral_protease; Papain like viral protease
    pfam16348
    Location:2847 → 2938
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    pfam19212
    Location:741 → 898
    CoV_NSP2_C; Coronavirus replicase NSP2, C-terminal
    cd21826
    Location:3522 → 3604
    alphaCoV_Nsp7; alphacoronavirus non-structural protein 7
    cd21830
    Location:3605 → 3799
    alphaCoV_Nsp8; alphacoronavirus non-structural protein 8
    cd21901
    Location:3909 → 4038
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
    cd21897
    Location:3800 → 3908
    alphaCoV_Nsp9; alphacoronavirus non-structural protein 9
    cd21875
    Location:3 → 110
    PEDV-like_alphaCoV_Nsp1; non-structural protein 1 from porcine epidemic diarrhea virus and similar alphacoronaviruses
    cd21731
    Location:1581 → 1868
    alphaCoV_PLPro; alphacoronavirus papain-like protease
    cd21712
    Location:1960 → 2460
    TM_Y_alphaCoV_Nsp3_C; C-terminus of alphacoronavirus non-structural protein 3, including transmembrane and Y domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6X5.1

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