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HCNV63gp2 spike protein [ Human coronavirus NL63 ]

Gene ID: 2943499, updated on 18-Aug-2023

Summary

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Gene symbol
HCNV63gp2
Gene description
spike protein
Locus tag
HCNV63gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human coronavirus NL63 (strain: Amsterdam I)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Alphacoronavirus; Setracovirus
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Genomic context

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Sequence:
NC_005831.2 (20472..24542)

NC_005831.2Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene protein 3 Neighboring gene envelope protein Neighboring gene membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_005831.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy. Walls AC, et al. Nat Struct Mol Biol, 2016 Oct. PMID 27617430, Free PMC Article
  2. Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry. Lin HX, et al. Virus Res, 2011 Sep. PMID 21798295, Free PMC Article
  3. Interaction between the spike protein of human coronavirus NL63 and its cellular receptor ACE2. Pöhlmann S, et al. Adv Exp Med Biol, 2006. PMID 17037543, Free PMC Article
  4. Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors. Hofmann H, et al. J Virol, 2006 Sep. PMID 16912312, Free PMC Article
  5. Identification of a new human coronavirus. van der Hoek L, et al. Nat Med, 2004 Apr. PMID 15034574, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reports the 3.4-A-resolution cryo-EM reconstruction of the HCoV-NL63 coronavirus spike glycoprotein trimer, which mediates entry into host cells and is the main target of neutralizing antibodies during infection.
    Title: Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy.
  2. A total of 15 residues (Y498, V499, V531, G534, G537, D538, S540, G575, S576, E582, W585, Y590, T591, V593 and G594) within the receptor-binding domain were important for receptor binding and virus entry.
    Title: Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry.
  3. The highly homologous C-terminal parts of the NL63-S1 subunits in conjunction with distinct amino acids in the central regions of these proteins confer recognition of ACE2 and CD13, respectively.
    Title: Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors.
  4. analysis of spike protein of human coronavirus NL63 interaction with its cellular receptor ACE2
    Title: Interaction between the spike protein of human coronavirus NL63 and its cellular receptor ACE2.
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General protein information

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Preferred Names
spike protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005831.2 Reference assembly

    Range
    20472..24542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003767.1 spike protein [Human coronavirus NL63]

    See identical proteins and their annotated locations for YP_003767.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q5DIX7, Q5DIX8, Q5DIX9, Q5DIY0, Q6Q1S2, Q6R1L7
    UniProtKB/TrEMBL
    K4P2Y7
    Conserved Domains (3) summary
    pfam01600
    Location:204 → 610
    Corona_S1; Coronavirus S1 glycoprotein
    pfam19214
    Location:1317 → 1356
    CoV_S2_C; Coronavirus spike glycoprotein S2, intravirion
    cd22375
    Location:618 → 1294
    HCoV-NL63-229E-like_Spike_SD1-2_S1-S2_S2; SD-1 and SD-2 subdomains, the S1/S2 cleavage region, and the S2 fusion subunit of the spike (S) glycoproteins from HCoV-NL63, HCoV-229E, and related alphacoronavirus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
7KIP_A.1
7KIP_B.1
7KIP_C.1
Q6Q1S2.1

Gene LinkOut

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