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Pla2g2c phospholipase A2, group IIC [ Rattus norvegicus (Norway rat) ]

Gene ID: 29387, updated on 18-Sep-2024

Summary

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Official Symbol
Pla2g2cprovided by RGD
Official Full Name
phospholipase A2, group IICprovided by RGD
Primary source
RGD:3340
See related
EnsemblRapid:ENSRNOG00000016647 AllianceGenome:RGD:3340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Orthologous to human PLA2G2C (phospholipase A2 group IIC). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 21.9), Brain (RPKM 6.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pla2g2c in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156241142..156262368)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150959365..150981388)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157163672..157187654)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351047 Neighboring gene von Willebrand factor A domain containing 5B1 Neighboring gene uncharacterized LOC108351048 Neighboring gene UBX domain protein 10 Neighboring gene phospholipase A2, group IIF Neighboring gene phospholipase A2, group IID

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of novel rat and mouse low molecular weight Ca(2+)-dependent phospholipase A2s containing 16 cysteines. Chen J, et al. J Biol Chem, 1994 Sep 16. PMID 8083202
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
group IIC secretory phospholipase A2
Names
14 kDa phospholipase A2
GIIC sPLA2
PLA2-8
phosphatidylcholine 2-acylhydrolase 2C
phosphatidylcholine 2-acylhydrolase GIIC
phospholipase A2, group 2C
sPLA2-IIC
NP_062075.1
XP_006239204.1
XP_006239205.1
XP_038965296.1
XP_038965297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019202.2 → NP_062075.1  group IIC secretory phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_062075.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097325
    UniProtKB/Swiss-Prot
    P39878
    UniProtKB/TrEMBL
    A0A0G2K3F5, Q4V8L7
    Conserved Domains (1) summary
    smart00085
    Location:29 → 148
    PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    156241142..156262368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239143.5 → XP_006239205.1  group IIC secretory phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_006239205.1

    UniProtKB/Swiss-Prot
    P39878
    UniProtKB/TrEMBL
    A0A0G2K3F5, Q4V8L7
    Related
    ENSRNOP00000072615.1, ENSRNOT00000087072.3
    Conserved Domains (1) summary
    smart00085
    Location:29 → 148
    PA2c; Phospholipase A2

  2. XM_039109369.2 → XP_038965297.1  group IIC secretory phospholipase A2 isoform X1

    UniProtKB/Swiss-Prot
    P39878
    UniProtKB/TrEMBL
    A0A0G2K3F5, Q4V8L7
    Conserved Domains (1) summary
    smart00085
    Location:29 → 148
    PA2c; Phospholipase A2

  3. XM_006239142.5 → XP_006239204.1  group IIC secretory phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_006239204.1

    UniProtKB/Swiss-Prot
    P39878
    UniProtKB/TrEMBL
    A0A0G2K3F5, Q4V8L7
    Conserved Domains (1) summary
    smart00085
    Location:29 → 148
    PA2c; Phospholipase A2

  4. XM_039109368.2 → XP_038965296.1  group IIC secretory phospholipase A2 isoform X1

    UniProtKB/Swiss-Prot
    P39878
    UniProtKB/TrEMBL
    A0A0G2K3F5, Q4V8L7
    Conserved Domains (1) summary
    smart00085
    Location:29 → 148
    PA2c; Phospholipase A2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39878.2 GenPept UniProtKB/Swiss-Prot:P39878

Gene LinkOut

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