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Ganab glucosidase II alpha subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 293721, updated on 2-Nov-2024

Summary

Official Symbol
Ganabprovided by RGD
Official Full Name
glucosidase II alpha subunitprovided by RGD
Primary source
RGD:1309775
See related
EnsemblRapid:ENSRNOG00000019724 AllianceGenome:RGD:1309775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G2an
Summary
Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 358.7), Adrenal (RPKM 330.7) and 9 other tissues See more
Orthologs
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Genomic context

See Ganab in Genome Data Viewer
Location:
1q43
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215222918..215242808)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205793910..205813704)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225096558..225116384)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 98 Neighboring gene uncharacterized LOC102551607 Neighboring gene integrator complex subunit 5 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene retinal outer segment membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables glucan 1,3-alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucan 1,3-alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of glucosidase II complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutral alpha-glucosidase AB
Names
alpha glucosidase 2 alpha neutral subunit
glucosidase, alpha
glucosidase, alpha; neutral AB
neutral AB
NP_001385713.1
NP_001385714.1
XP_063142985.1
XP_063142986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398784.2NP_001385713.1  neutral alpha-glucosidase AB isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (2) summary
    cd06603
    Location:406873
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:264406
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
  2. NM_001398785.2NP_001385714.1  neutral alpha-glucosidase AB isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (2) summary
    cd06603
    Location:384851
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:242384
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215222918..215242808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286915.1XP_063142985.1  neutral alpha-glucosidase AB isoform X1

    Related
    ENSRNOP00000036123.3, ENSRNOT00000035650.4
  2. XM_063286916.1XP_063142986.1  neutral alpha-glucosidase AB isoform X2

    Related
    ENSRNOP00000087021.2, ENSRNOT00000105221.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106334.1: Suppressed sequence

    Description
    NM_001106334.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.