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Pkp3 plakophilin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293619, updated on 10-Oct-2024

Summary

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Official Symbol
Pkp3provided by RGD
Official Full Name
plakophilin 3provided by RGD
Primary source
RGD:1309133
See related
EnsemblRapid:ENSRNOG00000015152 AllianceGenome:RGD:1309133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-catenin binding activity; cadherin binding activity; and enzyme binding activity. Predicted to be involved in several processes, including desmosome assembly; negative regulation of mRNA catabolic process; and protein localization to plasma membrane. Predicted to be located in desmosome and nucleoplasm. Predicted to be part of messenger ribonucleoprotein complex. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Orthologous to human PKP3 (plakophilin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 31.6), Lung (RPKM 17.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pkp3 in Genome Data Viewer
Location:
1q41
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205617511..205628441)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196187914..196198843)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213884795..213897783)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 4 Neighboring gene single Ig and TIR domain containing Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC134485202 Neighboring gene RNA, U6 small nuclear 1205

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. van Hengel J, et al. Eur Heart J, 2013 Jan. PMID 23136403
  2. E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Gosavi P, et al. Cell Mol Life Sci, 2011 Apr. PMID 20859650, Free PMC Article
  3. Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Fischer-Kešo R, et al. Mol Cell Biol, 2014 Dec 1. PMID 25225333, Free PMC Article
  4. Assessment of splice variant-specific functions of desmocollin 1 in the skin. Cheng X, et al. Mol Cell Biol, 2004 Jan. PMID 14673151, Free PMC Article
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in desmosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G1/S phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plakophilin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106315.3 → NP_001099785.1  plakophilin-3 isoform 1

    See identical proteins and their annotated locations for NP_001099785.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HXN4, A6HXN7, D3ZJ50
    Related
    ENSRNOP00000020864.4, ENSRNOT00000020864.6
    Conserved Domains (2) summary
    cd00020
    Location:346 → 457
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:346 → 371
    ARM; armadillo repeat [structural motif]

  2. NM_001415818.1 → NP_001402747.1  plakophilin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5YBE4, A6HXN5
    Related
    ENSRNOP00000076597.1, ENSRNOT00000095418.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205617511..205628441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759982.4 → XP_008758204.1  plakophilin-3 isoform X1

    UniProtKB/TrEMBL
    A6HXN7
    Conserved Domains (2) summary
    cd00020
    Location:321 → 432
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:321 → 346
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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