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Stmn1 stathmin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29332, updated on 2-Nov-2024

Summary

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Official Symbol
Stmn1provided by RGD
Official Full Name
stathmin 1provided by RGD
Primary source
RGD:2992
See related
EnsemblRapid:ENSRNOG00000016810 AllianceGenome:RGD:2992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SMN; OP18; PP17; PP19; PR22; Lap18; prosolin
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including establishment of skin barrier; negative regulation of signal transduction; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including axonogenesis; mitotic spindle organization; and negative regulation of microtubule polymerization. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm and neuron projection. Orthologous to human STMN1 (stathmin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 2149.6), Brain (RPKM 1909.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stmn1 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151964308..151970843)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146680757..146687154)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152680412..152686807)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene platelet-activating factor acetylhydrolase 2 Neighboring gene uncharacterized LOC102546373 Neighboring gene uncharacterized LOC134487004 Neighboring gene uncharacterized LOC102546455 Neighboring gene progestin and adipoQ receptor family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats. Shan W, et al. J Mol Neurosci, 2020 Apr. PMID 31933182
  2. Stathmin is enriched in the developing corticospinal tract. Fuller HR, et al. Mol Cell Neurosci, 2015 Nov. PMID 26370173
  3. A single cDNA encodes two isoforms of stathmin, a developmentally regulated neuron-enriched phosphoprotein. Doye V, et al. J Biol Chem, 1989 Jul 25. PMID 2745432
  4. Homology between the cDNAs encoding phosphoprotein p19 and SCG10 reveals a novel mammalian gene family preferentially expressed in developing brain. Schubart UK, et al. DNA, 1989 Jul-Aug. PMID 2776625
  5. cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress. Yip YY, et al. J Biol Chem, 2014 Jan 24. PMID 24302736, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats.
    Title: Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats.
  2. Stathmin is enriched in the developing corticospinal tract
    Title: Stathmin is enriched in the developing corticospinal tract.
  3. Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity
    Title: Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
  4. JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress.
    Title: cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.
  5. Stathmin 1 expression was decreased in the experimental animals from 1 to 14 days postseizure and then significantly increased at Days 30 and 60.
    Title: Abnormal expression of stathmin 1 in brain tissue of patients with intractable temporal lobe epilepsy and a rat model.
  6. role of stathmin 1 in FcRI-mediated activation of cells of mast cell lineage and might shed light on the diverse response of these cells to IgE or IgE plus antigen.
    Title: A novel insight to the functional role of Stathmin 1 in IgE-mediated activation of RBL-2H3 cells.
  7. Stathmin 1 is involved in the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in PC12 cells subjected to serum starvation.
    Title: Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells.
  8. Stathmin expression increases in the uterus when stimulated by embryo implantation and decidualization and may play a role in the early stages of pregnancy.
    Title: Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats.
  9. Sustained stathmin levels in differentiating oligodendrocytes, because of overexpression, resulted in enhanced apoptotic susceptibility.
    Title: Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders.
  10. role for stathmin in the migration of newborn neurons in the adult brain
    Title: Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72884

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stathmin
Names
leukemia-associated phosphoprotein p18
metablastin
oncoprotein 18
phosphoprotein p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429881.1 → NP_001416810.1  stathmin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24

  2. NM_001429882.1 → NP_001416811.1  stathmin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24

  3. NM_001429883.1 → NP_001416812.1  stathmin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24

  4. NM_001429884.1 → NP_001416813.1  stathmin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24

  5. NM_017166.3 → NP_058862.1  stathmin

    See identical proteins and their annotated locations for NP_058862.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A0A8I5ZX99, A0A8L2QYX2, A6IT24
    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151964308..151970843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239123.5 → XP_006239185.1  stathmin isoform X1

    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

  2. XM_017593202.3 → XP_017448691.1  stathmin isoform X1

    Related
    ENSRNOP00000110210.1, ENSRNOT00000125023.1
    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

  3. XM_063287253.1 → XP_063143323.1  stathmin isoform X1

  4. XM_063287250.1 → XP_063143320.1  stathmin isoform X1

    Related
    ENSRNOP00000022574.7, ENSRNOT00000022574.7

  5. XM_063287252.1 → XP_063143322.1  stathmin isoform X1

    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24

  6. XM_063287251.1 → XP_063143321.1  stathmin isoform X1

    UniProtKB/Swiss-Prot
    P13668
    UniProtKB/TrEMBL
    A6IT24
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13668.2 GenPept UniProtKB/Swiss-Prot:P13668

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