Ddt D-dopachrome tautomerase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddtprovided by RGD
Official Full Name: D-dopachrome tautomeraseprovided by RGD
Primary source: RGD:61923
See related: EnsemblRapid:ENSRNOG00000083406 AllianceGenome:RGD:61923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine receptor binding activity; phenylpyruvate tautomerase activity; and protease binding activity. Predicted to be involved in several processes, including negative regulation of macrophage chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of tumor necrosis factor production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human DDT (D-dopachrome tautomerase) and DDTL (D-dopachrome tautomerase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1896.0), Kidney (RPKM 1045.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12883025..12886121)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12884216..12886687)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13827153..13829624)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury.
Title: D-dopachrome tautomerase activates COX2/PGE(2) pathway of astrocytes to mediate inflammation following spinal cord injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128155 (e-PCR)
- UniSTS:211463

RH142321 (e-PCR)
- UniSTS:231568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-dopachrome decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables D-dopachrome decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	ISO Inferred from Sequence Orthology more info
enables dopachrome isomerase activity	TAS Traceable Author Statement more info	PubMed
enables phenylpyruvate tautomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylpyruvate tautomerase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: D-dopachrome decarboxylase

Names: dopachrome isomerase

NP_077045.1

EC 4.1.1.84

XP_063135059.1

EC 4.1.1.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024131.2 → NP_077045.1 D-dopachrome decarboxylase

See identical proteins and their annotated locations for NP_077045.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P80254

UniProtKB/TrEMBL

A0A0F7RQJ6, A6JKH4

Conserved Domains (1) summary

pfam01187
Location:2 → 116

MIF; Macrophage migration inhibitory factor (MIF)