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Fbxo17 F-box protein 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292757, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxo17provided by RGD
Official Full Name
F-box protein 17provided by RGD
Primary source
RGD:1308308
See related
EnsemblRapid:ENSRNOG00000019942 AllianceGenome:RGD:1308308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbg4; Fbx17; Fbxo26
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO17 (F-box protein 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 14.7), Testes (RPKM 10.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo17 in Genome Data Viewer
Location:
1q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93129776..93151983)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84002276..84024455)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86903762..86919238)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC108349512 Neighboring gene uncharacterized LOC134485106 Neighboring gene F-box protein 27 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene coiled-coil glutamate-rich protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Glenn KA, et al. J Biol Chem, 2008 May 9. PMID 18203720, Free PMC Article
  2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
  3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box only protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013064.2 → NP_001013082.2  F-box only protein 17

    Status: VALIDATED

    Source sequence(s)
    BC079218, BE120593
    UniProtKB/Swiss-Prot
    Q6AY27
    Conserved Domains (2) summary
    pfam04300
    Location:100 → 273
    FBA; F-box associated region
    pfam12937
    Location:27 → 59
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93129776..93151983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104122.2 → XP_038960050.1  F-box only protein 17 isoform X1

    Related
    ENSRNOP00000093850.2, ENSRNOT00000102551.2
    Conserved Domains (2) summary
    pfam04300
    Location:100 → 273
    FBA; F-box associated region
    pfam12937
    Location:27 → 59
    F-box-like

  2. XM_063283339.1 → XP_063139409.1  F-box only protein 17 isoform X3

  3. XM_063283346.1 → XP_063139416.1  F-box only protein 17 isoform X5

  4. XM_063283351.1 → XP_063139421.1  F-box only protein 17 isoform X6

  5. XM_063283366.1 → XP_063139436.1  F-box only protein 17 isoform X9

  6. XM_063283343.1 → XP_063139413.1  F-box only protein 17 isoform X4

  7. XM_063283356.1 → XP_063139426.1  F-box only protein 17 isoform X6

  8. XM_063283338.1 → XP_063139408.1  F-box only protein 17 isoform X2

    UniProtKB/Swiss-Prot
    Q6AY27
    Related
    ENSRNOP00000027006.6, ENSRNOT00000027006.9

  9. XM_039104125.2 → XP_038960053.1  F-box only protein 17 isoform X1

    Conserved Domains (2) summary
    pfam04300
    Location:100 → 273
    FBA; F-box associated region
    pfam12937
    Location:27 → 59
    F-box-like

  10. XM_063283332.1 → XP_063139402.1  F-box only protein 17 isoform X1

  11. XM_063283336.1 → XP_063139406.1  F-box only protein 17 isoform X1

  12. XM_039104146.1 → XP_038960074.1  F-box only protein 17 isoform X7

    UniProtKB/TrEMBL
    A6J9K3
    Conserved Domains (1) summary
    pfam04300
    Location:45 → 164
    FBA; F-box associated region

  13. XM_039104166.1 → XP_038960094.1  F-box only protein 17 isoform X7

    UniProtKB/TrEMBL
    A6J9K3
    Conserved Domains (1) summary
    pfam04300
    Location:45 → 164
    FBA; F-box associated region

  14. XM_039104187.1 → XP_038960115.1  F-box only protein 17 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AKV1
    Conserved Domains (1) summary
    pfam04300
    Location:2 → 135
    FBA; F-box associated region

RNA

  1. XR_010064589.1 RNA Sequence

  2. XR_010064590.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY27.1 GenPept UniProtKB/Swiss-Prot:Q6AY27

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