Numbl NUMB-like, endocytic adaptor protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Numblprovided by RGD
Official Full Name: NUMB-like, endocytic adaptor proteinprovided by RGD
Primary source: RGD:1307579
See related: EnsemblRapid:ENSRNOG00000020867 AllianceGenome:RGD:1307579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in positive regulation of dendrite morphogenesis and regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 44.0), Uterus (RPKM 30.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91677437..91701415)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82549814..82573788)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (84067841..84091659)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

peripheral nerve injury induced a downregulation of Numbl in the sciatic nerve, which was associated with Schwann cell differentiation.
Title: Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation.
We show that NUMBL is expressed in the rat auditory sensory epithelium during cochlear development
Title: Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium.
Numb and Numbl may be intracellular targets for CaM-Ks, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein
Title: Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF406395 (e-PCR)
- UniSTS:248353

RH129503 (e-PCR)
- UniSTS:212807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in lateral ventricle development	IEA Inferred from Electronic Annotation more info
involved_in lateral ventricle development	ISO Inferred from Sequence Orthology more info
involved_in lateral ventricle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuroblast division in subventricular zone	IEA Inferred from Electronic Annotation more info
involved_in neuroblast division in subventricular zone	ISO Inferred from Sequence Orthology more info
involved_in neuroblast division in subventricular zone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: numb-like protein

Names: numb homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033888.2 → NP_001029060.2 numb-like protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q3MUI2

Conserved Domains (3) summary

PHA03247
Location:262 → 599

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:64 → 198

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:288 → 370

NumbF; NUMB domain
NM_001398697.1 → NP_001385626.1 numb-like protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

A1L1I3

Related

ENSRNOP00000054039.3, ENSRNOT00000057213.5

Conserved Domains (3) summary

PHA03247
Location:259 → 600

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:64 → 198

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:289 → 371

NumbF; NUMB domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

91677437..91701415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104071.2 → XP_038959999.1 numb-like protein isoform X3

UniProtKB/TrEMBL

Q3MUI2

Conserved Domains (3) summary

PHA03247
Location:218 → 559

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:23 → 157

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:248 → 330

NumbF; NUMB domain
XM_006228566.5 → XP_006228628.1 numb-like protein isoform X2

UniProtKB/TrEMBL

Q3MUI2

Conserved Domains (2) summary

cd01268
Location:91 → 225

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:313 → 397

NumbF; NUMB domain
XM_006228565.5 → XP_006228627.1 numb-like protein isoform X1

UniProtKB/TrEMBL

A0A0G2K9C5, Q3MUI2

Conserved Domains (2) summary

cd01268
Location:91 → 225

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:314 → 398

NumbF; NUMB domain