Katna1 katanin catalytic subunit A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Katna1provided by RGD
Official Full Name: katanin catalytic subunit A1provided by RGD
Primary source: RGD:1303062
See related: EnsemblRapid:ENSRNOG00000014996 AllianceGenome:RGD:1303062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP hydrolysis activity; dynein complex binding activity; and microtubule severing ATPase activity. Involved in microtubule severing and negative regulation of neuron projection development. Located in growth cone and neuronal cell body. Orthologous to human KATNA1 (katanin catalytic subunit A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 109.1), Spleen (RPKM 88.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (4022886..4064513)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (2202501..2244132)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (1826170..1867786)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
Title: WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.
Title: RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.
Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.
Title: Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.
two modes by which microtubule severing occurs during axonal branch formation, based on the concentration of spastin at branch sites and on local detachment from microtubules of molecules such as tau that regulate the severing properties of P60-katanin
Title: The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.
the ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. Suggested that the effects on neuronal morphology are dependent on the degree of microtubule severing and loss of polymer
Title: Regulation of microtubule severing by katanin subunits during neuronal development.
When katanin is overexpressed in fibroblasts, the microtubules are severed into short pieces, but this phenomenon is suppressed by the coexpression of tau.
Title: Tau protects microtubules in the axon from severing by katanin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135174 (e-PCR)
- UniSTS:218451

d1rat246 (e-PCR)
- UniSTS:121481

RH125418 (e-PCR)
- UniSTS:162240

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	TAS Traceable Author Statement more info	PubMed
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	TAS Traceable Author Statement more info	PubMed
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule severing ATPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule severing	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
part_of katanin complex	IEA Inferred from Electronic Annotation more info
part_of katanin complex	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: katanin p60 ATPase-containing subunit A1

Names: katanin p60 subunit A 1; katanin p60 subunit A1; microtubule severing protein; p60 katanin

NP_001004217.2

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004217.4 → NP_001004217.2 katanin p60 ATPase-containing subunit A1

See identical proteins and their annotated locations for NP_001004217.2

Status: VALIDATED

Source sequence(s)

BC097929, BI302698

UniProtKB/Swiss-Prot

Q4V7G3, Q6E0V2

UniProtKB/TrEMBL

A6JP17, Z4YNM2

Related

ENSRNOP00000020417.4, ENSRNOT00000020417.8

Conserved Domains (3) summary

smart00382
Location:243 → 384

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:247 → 383

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:458 → 491

Vps4_C; Vps4 C terminal oligomerization domain