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Stmn3 stathmin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29246, updated on 2-Nov-2024

Summary

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Official Symbol
Stmn3provided by RGD
Official Full Name
stathmin 3provided by RGD
Primary source
RGD:3628
See related
EnsemblRapid:ENSRNOG00000013657 AllianceGenome:RGD:3628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sclip
Summary
Enables protein-folding chaperone binding activity. Involved in cellular response to nerve growth factor stimulus. Located in cytosol and perinuclear region of cytoplasm. Orthologous to human STMN3 (stathmin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1907.3) See more
Orthologs
human mouse all
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Genomic context

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See Stmn3 in Genome Data Viewer
Location:
3q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188794358..188802494, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168416810..168424946, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176808016..176816108, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger 2 Neighboring gene uncharacterized LOC120101833 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene zinc finger CCCH-type and G-patch domain containing Neighboring gene Lck interacting transmembrane adaptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor. Poulain FE, et al. J Neurosci, 2008 Jul 16. PMID 18632943, Free PMC Article
  2. The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10. Poulain FE, et al. Mol Cell Neurosci, 2007 Feb. PMID 17145186
  3. Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases. Levy AD, et al. Mol Biol Cell, 2011 Jun 1. PMID 21471001, Free PMC Article
  4. Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons. Devaux S, et al. J Biol Chem, 2012 Jun 22. PMID 22577147, Free PMC Article
  5. SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. Baldassa S, et al. J Biol Chem, 2007 Jan 26. PMID 17135267

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons
    Title: Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons.
  2. palmitoylation of stathmins 2 and 3 likely occurs at the Golgi and is crucial for their specific subcellular localization and trafficking
    Title: Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.
  3. SCLIP specifically accumulates in the growing dendrites of Purkinje cells (PC)during cerebellar development and is critical for both the formation and development of PC dendritic arbors at early and late stages of postnatal dendritogenesis.
    Title: SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.
  4. Clusterin interacts with SCLIP in PC12 cells and the interaction may act as an important modulator during neuronal differentiation.
    Title: Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells.
  5. A novel function for SCLIP in axonal morphogenesis, our results demonstrate for the first time that stathmin family proteins fulfill different and complementary roles during neuronal differentiation.
    Title: The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rac protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stathmin-3
Names
SCG10-like protein
scgn10 like-protein
stathmin-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395145.1 → NP_001382074.1  stathmin-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9JHU6
    UniProtKB/TrEMBL
    A6KM20, D3ZI49
    Related
    ENSRNOP00000089824.1, ENSRNOT00000109405.2
    Conserved Domains (1) summary
    pfam00836
    Location:39 → 175
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188794358..188802494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283198.1 → XP_063139268.1  stathmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8P5, A6KM21
    Related
    ENSRNOP00000018697.5, ENSRNOT00000018697.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001395063.1: Suppressed sequence

    Description
    NM_001395063.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_024346.2: Suppressed sequence

    Description
    NM_024346.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHU6.1 GenPept UniProtKB/Swiss-Prot:Q9JHU6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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