Sqle squalene epoxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sqleprovided by RGD
Official Full Name: squalene epoxidaseprovided by RGD
Primary source: RGD:3755
See related: EnsemblRapid:ENSRNOG00000009550 AllianceGenome:RGD:3755
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables squalene monooxygenase activity. Involved in cholesterol metabolic process and response to biphenyl. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 180.8), Liver (RPKM 136.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (92758175..92773049)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (90867973..90883623)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (99609929..99624803)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

functional promotor regions involved in transcription was determined
Title: SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.
Phosphorylation of supernatant protein factor enhances its ability to stimulate this enzyme in liver microsomes.
Title: Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.
aromatic residues are likely to be located at the substrate-binding domain of the active-site, and control the stereochemical course of the squalene epoxidase reaction
Title: Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133886 (e-PCR)
- UniSTS:217169

RH130198 (e-PCR)
- UniSTS:213485

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables squalene monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables squalene monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables squalene monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables squalene monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to biphenyl	IDA Inferred from Direct Assay more info	PubMed
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: squalene monooxygenase

Names: SE

NP_058832.1

EC 1.14.14.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017136.2 → NP_058832.1 squalene monooxygenase

See identical proteins and their annotated locations for NP_058832.1

Status: PROVISIONAL

Source sequence(s)

BC097330

UniProtKB/Swiss-Prot

P52020, Q4V8L3

UniProtKB/TrEMBL

A0A8I6AKW2, A6HRM0

Related

ENSRNOP00000012883.2, ENSRNOT00000012883.6

Conserved Domains (2) summary

COG0654
Location:124 → 498

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

cl21454
Location:276 → 547

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins