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St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291325, updated on 17-Aug-2024

Summary

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Official Symbol
St8sia6provided by RGD
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by RGD
Primary source
RGD:1303161
See related
EnsemblRapid:ENSRNOG00000064205 AllianceGenome:RGD:1303161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat8f
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to act upstream of or within several processes, including blastocyst hatching; glycolipid biosynthetic process; and protein O-linked glycosylation. Predicted to be located in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 23.7), Spleen (RPKM 20.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St8sia6 in Genome Data Viewer
Location:
17q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81649866..81847970, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76740755..76884178, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80960785..81002830, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene vimentin Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene signal transducing adaptor molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. Takashima S, et al. J Biol Chem, 2002 Jul 5. PMID 11980897
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8F
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
alpha 2,8-sialyltransferase
sialyltransferase 8F (alpha-2, 8-sialyltransferase)
NP_998789.1
XP_038951485.1
XP_038951486.1
XP_063132323.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213624.2 → NP_998789.1  alpha-2,8-sialyltransferase 8F

    See identical proteins and their annotated locations for NP_998789.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6AV23, A6JM47, Q6ZXC7
    Related
    ENSRNOP00000091997.1, ENSRNOT00000098074.2
    Conserved Domains (1) summary
    pfam00777
    Location:138 → 391
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    81649866..81847970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276253.1 → XP_063132323.1  alpha-2,8-sialyltransferase 8F isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV23, A6JM47, Q6ZXC7

  2. XM_039095558.2 → XP_038951486.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:1 → 240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_039095557.2 → XP_038951485.1  alpha-2,8-sialyltransferase 8F isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:133 → 386
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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