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Nmt2 N-myristoyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291318, updated on 14-Nov-2024

Summary

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Official Symbol
Nmt2provided by RGD
Official Full Name
N-myristoyltransferase 2provided by RGD
Primary source
RGD:1303175
See related
EnsemblRapid:ENSRNOG00000026248 AllianceGenome:RGD:1303175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and protein localization to membrane. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 249.4), Adrenal (RPKM 227.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nmt2 in Genome Data Viewer
Location:
17q12.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79826999..79874088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74917833..74964788, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78919235..78966013, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482748 Neighboring gene U4 spliceosomal RNA Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene uncharacterized LOC134482749 Neighboring gene uncharacterized LOC134482750 Neighboring gene integrin subunit alpha 8 Neighboring gene uncharacterized LOC120097958

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis. Sun Y, et al. J Psychiatr Res, 2024 Aug. PMID 38852542
  2. Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases. Rioux V, et al. Mol Cell Biochem, 2006 Jun. PMID 16538398
  3. Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2. Kolluri SK, et al. Cancer Res, 2001 Dec 1. PMID 11731439
  4. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Thinon E, et al. Nat Commun, 2014 Sep 26. PMID 25255805, Free PMC Article
  5. A second mammalian N-myristoyltransferase. Giang DK, et al. J Biol Chem, 1998 Mar 20. PMID 9506952

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
    Title: NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
  2. NMT2 protein exhibited functional myristoyltransferase activity, but appeared to be 4-time less active than NMT1.
    Title: Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptidyl-lysine N6-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-glycine N-myristoylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in N-terminal protein myristoylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycylpeptide N-tetradecanoyltransferase 2
NP_001399348.1
NP_997473.2
XP_008770076.1
XP_017455983.1
XP_038951470.1
XP_063132313.1
XP_063132314.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412419.1 → NP_001399348.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    F1M110
    Related
    ENSRNOP00000035716.6, ENSRNOT00000030228.7

  2. NM_207590.2 → NP_997473.2  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6JM25
    Related
    ENSRNOP00000078750.2, ENSRNOT00000112511.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    79826999..79874088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276243.1 → XP_063132313.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

  2. XM_017600494.3 → XP_017455983.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A8X5

  3. XM_039095542.2 → XP_038951470.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8X5
    Conserved Domains (1) summary
    COG5092
    Location:125 → 492
    NMT1; N-myristoyl transferase [Lipid metabolism]

  4. XM_063276244.1 → XP_063132314.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZWZ4
    Related
    ENSRNOP00000083953.1, ENSRNOT00000119939.2

  5. XM_008771854.4 → XP_008770076.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8X5, A0A8I6A9A8
    Related
    ENSRNOP00000090038.1, ENSRNOT00000099682.2
    Conserved Domains (2) summary
    pfam01233
    Location:144 → 298
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:314 → 489
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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