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Syn3 synapsin III [ Rattus norvegicus (Norway rat) ]

Gene ID: 29130, updated on 2-Nov-2024

Summary

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Symbol
Syn3provided by RGD
Full Name
synapsin IIIprovided by RGD
Primary source
RGD:3799
See related
EnsemblRapid:ENSRNOG00000026866 AllianceGenome:RGD:3799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP binding activity. Predicted to be involved in synapse organization and synaptic vesicle clustering. Located in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Orthologous to human SYN3 (synapsin III). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 40.9), Kidney (RPKM 19.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Syn3 in Genome Data Viewer
Location:
7q13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19244032..19701571)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (16216055..17808790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (23403896..23808602)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479846 Neighboring gene sperm motility kinase W like 2 Neighboring gene TIMP metallopeptidase inhibitor 3 Neighboring gene uncharacterized LOC134479850 Neighboring gene uncharacterized LOC134479849 Neighboring gene U6 spliceosomal RNA Neighboring gene F-box protein 7 Neighboring gene BPI fold containing family C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of neurotransmitter release by synapsin III. Feng J, et al. J Neurosci, 2002 Jun 1. PMID 12040043, Free PMC Article
  2. Synapsin III, a novel synapsin with an unusual regulation by Ca2+. Hosaka M, et al. J Biol Chem, 1998 May 29. PMID 9593663
  3. A third member of the synapsin gene family. Kao HT, et al. Proc Natl Acad Sci U S A, 1998 Apr 14. PMID 9539796, Free PMC Article
  4. Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo. Perlini LE, et al. Cell Rep, 2015 Apr 14. PMID 25843720, Free PMC Article
  5. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, et al. Mol Biol Cell, 2007 Jul. PMID 17442889, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we show that SynIII phosphorylation at the CDK5 site is induced by activation of the semaphorin-3A (Sema3A) pathway, which is implicated in migration and orientation of cortical pyramidal neurons
    Title: Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synapsin-3
Names
synapsin-3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017109.2 → NP_058805.1  synapsin-3

    See identical proteins and their annotated locations for NP_058805.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O70441
    UniProtKB/TrEMBL
    A0A096MIT7, A6IFC2
    Related
    ENSRNOP00000036740.6, ENSRNOT00000037918.7
    Conserved Domains (4) summary
    PRK14971
    Location:380 → 530
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam02750
    Location:192 → 394
    Synapsin_C; Synapsin, ATP binding domain
    pfam02078
    Location:90 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    19244032..19701571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263103.1 → XP_063119173.1  synapsin-3 isoform X1

    UniProtKB/Swiss-Prot
    O70441
    UniProtKB/TrEMBL
    A6IFC2

  2. XM_063263102.1 → XP_063119172.1  synapsin-3 isoform X1

    UniProtKB/Swiss-Prot
    O70441
    UniProtKB/TrEMBL
    A6IFC2

  3. XM_063263105.1 → XP_063119175.1  synapsin-3 isoform X1

    UniProtKB/Swiss-Prot
    O70441
    UniProtKB/TrEMBL
    A6IFC2

  4. XM_063263104.1 → XP_063119174.1  synapsin-3 isoform X1

    UniProtKB/Swiss-Prot
    O70441
    UniProtKB/TrEMBL
    A6IFC2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70441.1 GenPept UniProtKB/Swiss-Prot:O70441

Gene LinkOut

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