U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eci2 enoyl-CoA delta isomerase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291075, updated on 19-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Eci2provided by RGD
Official Full Name
enoyl-CoA delta isomerase 2provided by RGD
Primary source
RGD:1359427
See related
EnsemblRapid:ENSRNOG00000066714 AllianceGenome:RGD:1359427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Peci
Summary
Enables dodecenoyl-CoA delta-isomerase activity. Involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 875.7), Heart (RPKM 764.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eci2 in Genome Data Viewer
Location:
17p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (30056274..30092169)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (29850884..29886781)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (30556926..30573324)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene endoplasmic reticulum protein 29, pseudogene 1 Neighboring gene testis expressed 56 Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene family with sequence similarity 217, member A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10. Onwukwe GU, et al. FEBS J, 2015 Feb. PMID 25515061
  2. Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes. Geisbrecht BV, et al. J Biol Chem, 1999 Jul 30. PMID 10419495
  3. Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase. van Weeghel M, et al. FASEB J, 2014 Mar. PMID 24344334
  4. Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver. Zhang D, et al. J Biol Chem, 2002 Mar 15. PMID 11781327
  5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94706

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular oxidoreductase activity, transposing C=C bonds IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
enoyl-CoA delta isomerase 2
Names
D3,D2-enoyl-CoA isomerase
delta(3),delta(2)-enoyl-CoA isomerase
dodecenoyl-CoA isomerase
enoyl-CoA delta isomerase 2, mitochondrial
enoyl-Coenzyme A delta isomerase 2
peroxisomal 3,2-trans-enoyl-CoA isomerase
peroxisomal D3,D2-enoyl-CoA isomerase
peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase
NP_001006967.1
XP_038951410.1
XP_038951411.1
XP_038951412.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006966.1 → NP_001006967.1  enoyl-CoA delta isomerase 2 precursor

    See identical proteins and their annotated locations for NP_001006967.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083764
    UniProtKB/Swiss-Prot
    Q5XIC0
    Conserved Domains (2) summary
    pfam00887
    Location:38 → 113
    ACBP; Acyl CoA binding protein
    cl23717
    Location:134 → 389
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    30056274..30092169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095482.1 → XP_038951410.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2, A6J7E6
    Related
    ENSRNOP00000022022.4, ENSRNOT00000022022.8
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. XM_039095484.2 → XP_038951412.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2, A6J7E6
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  3. XM_039095483.2 → XP_038951411.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2, A6J7E6
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIC0.1 GenPept UniProtKB/Swiss-Prot:Q5XIC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous