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Zmiz2 zinc finger, MIZ-type containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289783, updated on 2-Nov-2024

Summary

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Symbol
Zmiz2provided by RGD
Full Name
zinc finger, MIZ-type containing 2provided by RGD
Primary source
RGD:1309256
See related
EnsemblRapid:ENSRNOG00000025923 AllianceGenome:RGD:1309256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309256
Summary
Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to be located in chromatin; mitochondrion; and nuclear lumen. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 51.3), Thymus (RPKM 43.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zmiz2 in Genome Data Viewer
Location:
14q21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85465323..85481860)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81251391..81267936)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86645875..86662419)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) 26 Neighboring gene oxoglutarate dehydrogenase Neighboring gene U4 spliceosomal RNA Neighboring gene small Cajal body-specific RNA 16 Neighboring gene peptidylprolyl isomerase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Huang CY, et al. Mol Endocrinol, 2005 Dec. PMID 16051670
  2. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. Li X, et al. J Biol Chem, 2006 Aug 18. PMID 16777850
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MIZ domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100507.1 → NP_001093977.1  zinc finger MIZ domain-containing protein 2

    See identical proteins and their annotated locations for NP_001093977.1

    Status: VALIDATED

    Source sequence(s)
    AW528357, BC079401, CK364743, CK473991, CV111150, DY312973, JAXUCZ010000014
    UniProtKB/TrEMBL
    A6IKT5, G3V9C9
    Related
    ENSRNOP00000042684.3, ENSRNOT00000052002.6
    Conserved Domains (2) summary
    PHA03378
    Location:683 → 886
    PHA03378; EBNA-3B; Provisional
    cd16791
    Location:597 → 644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    85465323..85481860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272960.1 → XP_063129030.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  2. XM_063272957.1 → XP_063129027.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  3. XM_063272967.1 → XP_063129037.1  zinc finger MIZ domain-containing protein 2 isoform X3

  4. XM_063272969.1 → XP_063129039.1  zinc finger MIZ domain-containing protein 2 isoform X4

  5. XM_063272965.1 → XP_063129035.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6IKT5, G3V9C9

  6. XM_039091751.2 → XP_038947679.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6IKT5, G3V9C9
    Conserved Domains (2) summary
    PHA03378
    Location:683 → 886
    PHA03378; EBNA-3B; Provisional
    cd16791
    Location:597 → 644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  7. XM_063272970.1 → XP_063129040.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A6IKT6
    Related
    ENSRNOP00000099615.1, ENSRNOT00000139159.1

  8. XM_063272963.1 → XP_063129033.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  9. XM_063272961.1 → XP_063129031.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  10. XM_063272972.1 → XP_063129042.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A6IKT6

  11. XM_063272959.1 → XP_063129029.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  12. XM_017599125.3 → XP_017454614.1  zinc finger MIZ domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JUU0
    Related
    ENSRNOP00000069227.2, ENSRNOT00000077428.3
    Conserved Domains (1) summary
    pfam02891
    Location:570 → 618
    zf-MIZ; MIZ/SP-RING zinc finger

  13. XM_063272968.1 → XP_063129038.1  zinc finger MIZ domain-containing protein 2 isoform X4

  14. XM_006251440.5 → XP_006251502.1  zinc finger MIZ domain-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006251502.1

    UniProtKB/TrEMBL
    A6IKT6
    Conserved Domains (1) summary
    pfam02891
    Location:564 → 612
    zf-MIZ; MIZ/SP-RING zinc finger

  15. XM_008770269.4 → XP_008768491.1  zinc finger MIZ domain-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_008768491.1

    Conserved Domains (1) summary
    pfam02891
    Location:538 → 586
    zf-MIZ; MIZ/SP-RING zinc finger

  16. XM_063272974.1 → XP_063129044.1  zinc finger MIZ domain-containing protein 2 isoform X8

  17. XM_063272971.1 → XP_063129041.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A6IKT6
    Related
    ENSRNOP00000081352.2, ENSRNOT00000108819.2

  18. XM_063272973.1 → XP_063129043.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A6IKT6

  19. XM_063272962.1 → XP_063129032.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9

  20. XM_063272966.1 → XP_063129036.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6IKT5, G3V9C9

  21. XM_063272958.1 → XP_063129028.1  zinc finger MIZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF9
Nucleotide Protein Strain
Heading Accession and Version

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