U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plcd3 phospholipase C, delta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287745, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Plcd3provided by RGD
Official Full Name
phospholipase C, delta 3provided by RGD
Primary source
RGD:1310903
See related
EnsemblRapid:ENSRNOG00000003033 AllianceGenome:RGD:1310903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to act upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Located in cytosol and membrane. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 74.8), Adrenal (RPKM 36.9) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Plcd3 in Genome Data Viewer
Location:
10q32.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88526802..88548116, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88026707..88048080, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91164778..91186067, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene complement C1q like 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene N-myristoyltransferase 1 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene HEXIM P-TEFb complex subunit 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. Pawelczyk T, et al. Eur J Biochem, 1998 Oct 1. PMID 9799116
  2. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Nakamura Y, et al. Cell Death Dis, 2014 May 8. PMID 24810051, Free PMC Article
  3. Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Nakamura Y, et al. Mol Cell Biol, 2005 Dec. PMID 16314520, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
    Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
NP_001099315.3
XP_017452628.1
XP_017452629.1
XP_017452631.1
XP_038941555.1
XP_038941556.1
XP_038941557.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105845.3 → NP_001099315.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A978
    Related
    ENSRNOP00000112234.1, ENSRNOT00000149994.1
    Conserved Domains (4) summary
    cd08630
    Location:332 → 627
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:251 → 783
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:61 → 177
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:197 → 246
    EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88526802..88548116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085627.2 → XP_038941555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

    UniProtKB/TrEMBL
    D4A978
    Conserved Domains (4) summary
    PLN02228
    Location:251 → 782
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:61 → 177
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:197 → 246
    EF-hand_10; EF hand
    cl14615
    Location:332 → 626
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. XM_017597142.3 → XP_017452631.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

    UniProtKB/TrEMBL
    D4A978
    Conserved Domains (4) summary
    cd08630
    Location:272 → 567
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:191 → 723
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:1 → 117
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:137 → 186
    EF-hand_10; EF hand

  3. XM_017597139.3 → XP_017452628.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGE0, D4A978
    Related
    ENSRNOP00000091874.1, ENSRNOT00000099178.2

  4. XM_017597140.3 → XP_017452629.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGE0, D4A978

  5. XM_039085628.2 → XP_038941556.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

    UniProtKB/TrEMBL
    D4A978
    Conserved Domains (4) summary
    cd08630
    Location:272 → 567
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:191 → 723
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:1 → 117
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:137 → 186
    EF-hand_10; EF hand

  6. XM_039085629.2 → XP_038941557.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X4

    Conserved Domains (3) summary
    cd13363
    Location:61 → 177
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16218
    Location:182 → 320
    EFh_PI-PLCdelta3; EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)
    cl14615
    Location:332 → 605
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools