ANK2 ankyrin 2 [ Homo sapiens (human) ]

Gene ID: 287, updated on 3-Nov-2024

Summary

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Official Symbol: ANK2provided by HGNC
Official Full Name: ankyrin 2provided by HGNC
Primary source: HGNC:HGNC:493
See related: Ensembl:ENSG00000145362 MIM:106410; AllianceGenome:HGNC:493
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LQT4; ANK-2; FAP87; CFAP87; brank-2
Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Expression: Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

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See ANK2 in Genome Data Viewer

Location:: 4q25-q26

Exon count:: 61

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (112705622..113383736)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (116013980..116692458)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (113626778..114304892)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants.
Title: Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants.
ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
Title: ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
Human ankyrins and their contribution to disease biology: An update.
Title: Human ankyrins and their contribution to disease biology: An update.
lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
Title: lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
Title: Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
Title: Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
Title: Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
Title: ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
Title: Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cardiac arrhythmia, ankyrin-B-related MedGen: C1970119 OMIM: 600919 GeneReviews: Long QT Syndrome Overview	Compare labs

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies loci affecting blood copper, selenium and zinc. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4S2542E (e-PCR)
- UniSTS:23040

D11S2921 (e-PCR)
- UniSTS:152074

NoName (e-PCR)
- UniSTS:9484

AFM186xb4 (e-PCR), detects polymorphism
- UniSTS:84752

SHGC-59287 (e-PCR)
- UniSTS:3352

SHGC-132360 (e-PCR)
- UniSTS:170793

SHGC-83197 (e-PCR)
- UniSTS:95789

WIAF-2193 (e-PCR)
- UniSTS:5702

SHGC-24748 (e-PCR)
- UniSTS:83025

SHGC-11962 (e-PCR)
- UniSTS:14677

L18426 (e-PCR)
- UniSTS:34648

SHGC-82082 (e-PCR)
- UniSTS:103011

SHGC-23907 (e-PCR)
- UniSTS:74347

D4S2309 (e-PCR)
- UniSTS:149363

SHGC-81181 (e-PCR)
- UniSTS:102006

SHGC-59553 (e-PCR)
- UniSTS:79233

RH119774 (e-PCR)
- UniSTS:133250

WI-19148 (e-PCR)
- UniSTS:64392

SHGC-14389 (e-PCR)
- UniSTS:71608

SHGC-148725 (e-PCR)
- UniSTS:176582

SHGC-50779 (e-PCR)
- UniSTS:38343

ANK2_3170 (e-PCR)
- UniSTS:462025

SHGC-83104 (e-PCR)
- UniSTS:101330

SHGC-23852 (e-PCR)
- UniSTS:74974

SHGC-67324 (e-PCR)
- UniSTS:85726

SHGC-84192 (e-PCR)
- UniSTS:104688

NIB1562 (e-PCR)
- UniSTS:13305

SHGC-79494 (e-PCR)
- UniSTS:103417

Clone Names

FLJ11832, FLJ38277, FLJ46169, DKFZp686P0948, DKFZp686M09125

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal anchor activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphorylation-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables spectrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in SA node cell to atrial cardiac muscle cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-tubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial cardiac muscle cell to AV node cell communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in atrial septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during SA node cell action potential	TAS Traceable Author Statement more info	PubMed
involved_in paranodal junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of potassium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to M-band	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to T-tubule	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to organelle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of SA node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of calcium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by calcium ion signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IC Inferred by Curator more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to methylmercury	IEA Inferred from Electronic Annotation more info
involved_in sarcoplasmic reticulum calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in A band	ISS Inferred from Sequence or Structural Similarity more info
located_in M band	ISS Inferred from Sequence or Structural Similarity more info
located_in T-tubule	ISS Inferred from Sequence or Structural Similarity more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ankyrin-2

Names: ankyrin 2, neuronal; ankyrin B; ankyrin, brain; ankyrin-2, nonerythrocytic; non-erythroid ankyrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009006.2 RefSeqGene

Range

5001..570658

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_327

mRNA and Protein(s)

NM_001127493.3 → NP_001120965.1 ankyrin-2 isoform 3

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS54796.1

UniProtKB/Swiss-Prot

Q01484

Related

ENSP00000421067.1, ENST00000506722.5

Conserved Domains (9) summary

pfam06390
Location:1629 → 1786

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:957 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00248
Location:508 → 533

ANK; ankyrin repeats

COG0666
Location:285 → 483

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1473 → 1556

Death_ank2; Death domain of Ankyrin-2

pfam12796
Location:216 → 307

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:16 → 63

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]
NM_001148.6 → NP_001139.3 ankyrin-2 isoform 1

See identical proteins and their annotated locations for NP_001139.3

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS3702.1

UniProtKB/Swiss-Prot

Q01484, Q01485, Q08AC7, Q08AC8, Q7Z3L5

UniProtKB/TrEMBL

I6L894

Related

ENSP00000349588.4, ENST00000357077.9

Conserved Domains (11) summary

pfam06390
Location:3723 → 3880

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

pfam09528
Location:2071 → 2594

Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)

smart00218
Location:966 → 1103

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00248
Location:529 → 554

ANK; ankyrin repeats

COG0666
Location:306 → 504

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:3567 → 3650

Death_ank2; Death domain of Ankyrin-2

pfam12796
Location:237 → 328

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:37 → 84

Ank_4; Ankyrin repeats (many copies)

pfam15718
Location:1877 → 2169

DUF4673; Domain of unknown function (DUF4673)

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]
NM_001354225.2 → NP_001341154.1 ankyrin-2 isoform 4

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Conserved Domains (6) summary

pfam06390
Location:1642 → 1799

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:970 → 1107

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1486 → 1569

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354228.2 → NP_001341157.1 ankyrin-2 isoform 5

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93591.1

UniProtKB/TrEMBL

A0A5F9ZH70

Related

ENSP00000500102.1, ENST00000671727.1

Conserved Domains (6) summary

pfam06390
Location:1605 → 1742

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:966 → 1070

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1449 → 1532

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354230.2 → NP_001341159.1 ankyrin-2 isoform 6

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (6) summary

pfam06390
Location:1631 → 1788

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:992 → 1096

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1475 → 1558

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354231.2 → NP_001341160.1 ankyrin-2 isoform 7

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (6) summary

pfam06390
Location:1652 → 1789

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:980 → 1117

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1496 → 1579

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354232.2 → NP_001341161.1 ankyrin-2 isoform 8

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93590.1

UniProtKB/TrEMBL

A0A5F9ZI81

Related

ENSP00000500954.1, ENST00000671762.1

Conserved Domains (6) summary

pfam06390
Location:1650 → 1787

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:978 → 1115

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1494 → 1577

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354235.2 → NP_001341164.1 ankyrin-2 isoform 9

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Conserved Domains (6) summary

pfam06390
Location:1637 → 1774

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:965 → 1102

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1481 → 1564

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354236.2 → NP_001341165.1 ankyrin-2 isoform 10

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Conserved Domains (6) summary

pfam06390
Location:1604 → 1761

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:965 → 1069

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1448 → 1531

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354237.2 → NP_001341166.1 ankyrin-2 isoform 11

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (6) summary

pfam06390
Location:1664 → 1821

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:992 → 1129

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1508 → 1591

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354239.2 → NP_001341168.1 ankyrin-2 isoform 12

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (6) summary

pfam06390
Location:1628 → 1765

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:956 → 1093

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1472 → 1555

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354240.2 → NP_001341169.1 ankyrin-2 isoform 13

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93595.1

UniProtKB/TrEMBL

A0A5F9ZH39, A0A994J7V8

Related

ENSP00000499996.1, ENST00000673240.1

Conserved Domains (6) summary

pfam06390
Location:1653 → 1810

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:981 → 1118

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1497 → 1580

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354241.2 → NP_001341170.1 ankyrin-2 isoform 14

Status: REVIEWED

Source sequence(s)

AC004057, AC093617, AC093879, AC093900

Consensus CDS

CCDS93589.1

UniProtKB/TrEMBL

A0A5F9ZGY1

Related

ENSP00000499869.1, ENST00000672779.1

Conserved Domains (6) summary

pfam06390
Location:1653 → 1810

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:981 → 1118

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1497 → 1580

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354242.2 → NP_001341171.1 ankyrin-2 isoform 15

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (6) summary

pfam06390
Location:1652 → 1809

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:980 → 1117

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:242 → 367

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1496 → 1579

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:514 → 565

Ank_4; Ankyrin repeats (many copies)
NM_001354243.2 → NP_001341172.1 ankyrin-2 isoform 16

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93573.1

UniProtKB/TrEMBL

A0A5F9ZI56

Related

ENSP00000500881.1, ENST00000672402.1

Conserved Domains (6) summary

pfam06390
Location:1617 → 1754

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1082

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1461 → 1544

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354244.2 → NP_001341173.1 ankyrin-2 isoform 17

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (6) summary

pfam06390
Location:1616 → 1753

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:944 → 1081

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1460 → 1543

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354245.2 → NP_001341174.1 ankyrin-2 isoform 18

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93593.1

UniProtKB/TrEMBL

A0A5F9ZH17

Related

ENSP00000499959.1, ENST00000672045.1

Conserved Domains (6) summary

pfam06390
Location:1584 → 1741

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1049

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1428 → 1511

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:565 → 616

Ank_4; Ankyrin repeats (many copies)
NM_001354246.2 → NP_001341175.1 ankyrin-2 isoform 19

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Conserved Domains (6) summary

pfam06390
Location:1637 → 1794

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:965 → 1102

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1481 → 1564

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354249.2 → NP_001341178.1 ankyrin-2 isoform 20

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93582.1

UniProtKB/TrEMBL

A0A5F9ZGS5

Related

ENSP00000499837.1, ENST00000672088.1

Conserved Domains (6) summary

pfam06390
Location:1576 → 1733

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1420 → 1503

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:470 → 521

Ank_4; Ankyrin repeats (many copies)
NM_001354252.2 → NP_001341181.1 ankyrin-2 isoform 21

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (6) summary

pfam06390
Location:1628 → 1785

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:956 → 1093

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1472 → 1555

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354253.2 → NP_001341182.1 ankyrin-2 isoform 22

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93577.1

UniProtKB/TrEMBL

A0A5F9ZHL3

Related

ENSP00000500420.1, ENST00000672350.1

Conserved Domains (6) summary

pfam06390
Location:1563 → 1720

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:924 → 1028

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1407 → 1490

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:544 → 595

Ank_4; Ankyrin repeats (many copies)
NM_001354254.2 → NP_001341183.1 ankyrin-2 isoform 23

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (6) summary

pfam06390
Location:1621 → 1778

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:949 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1465 → 1548

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354255.2 → NP_001341184.1 ankyrin-2 isoform 24

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93574.1

UniProtKB/TrEMBL

A0A024RDI4, A0A5F9ZHJ6

Related

ENSP00000500459.1, ENST00000671825.1

Conserved Domains (6) summary

pfam06390
Location:1617 → 1774

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1082

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1461 → 1544

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354256.2 → NP_001341185.1 ankyrin-2 isoform 25

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (8) summary

pfam06390
Location:1616 → 1773

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:944 → 1081

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1460 → 1543

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1302 → 1431

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
NM_001354257.2 → NP_001341186.1 ankyrin-2 isoform 26

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93579.1

UniProtKB/TrEMBL

A0A5F9ZI36

Related

ENSP00000500833.1, ENST00000671854.1

Conserved Domains (6) summary

pfam06390
Location:1551 → 1708

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:912 → 1016

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1395 → 1478

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:544 → 595

Ank_4; Ankyrin repeats (many copies)
NM_001354258.2 → NP_001341187.1 ankyrin-2 isoform 27

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93592.1

UniProtKB/TrEMBL

A0A5F9ZI69

Related

ENSP00000500937.1, ENST00000672366.1

Conserved Domains (6) summary

pfam06390
Location:1605 → 1762

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:966 → 1070

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1449 → 1532

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354260.2 → NP_001341189.1 ankyrin-2 isoform 28

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93586.1

UniProtKB/TrEMBL

A0A5F9ZHQ3

Related

ENSP00000500544.1, ENST00000672356.1

Conserved Domains (6) summary

pfam06390
Location:1543 → 1700

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:904 → 1008

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1387 → 1470

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:536 → 587

Ank_4; Ankyrin repeats (many copies)
NM_001354261.2 → NP_001341190.1 ankyrin-2 isoform 29

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093617, AC093900

Conserved Domains (6) summary

pfam06390
Location:1591 → 1748

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:952 → 1056

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:213 → 338

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1435 → 1518

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:416 → 447

ANK; ANK repeat [structural motif]

pfam13637
Location:485 → 536

Ank_4; Ankyrin repeats (many copies)
NM_001354262.2 → NP_001341191.1 ankyrin-2 isoform 30

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93575.1

UniProtKB/TrEMBL

A0A5F9ZHJ4

Related

ENSP00000500378.1, ENST00000672312.1

Conserved Domains (6) summary

pfam06390
Location:1584 → 1741

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1049

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1428 → 1511

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354264.2 → NP_001341193.1 ankyrin-2 isoform 31

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93581.1

UniProtKB/TrEMBL

A0A5F9ZHL9

Related

ENSP00000500473.1, ENST00000672221.1

Conserved Domains (6) summary

pfam06390
Location:1583 → 1740

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1427 → 1510

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:470 → 521

Ank_4; Ankyrin repeats (many copies)
NM_001354265.2 → NP_001341194.1 ankyrin-2 isoform 32

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

B7Z636

Conserved Domains (6) summary

pfam06390
Location:1637 → 1794

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:965 → 1102

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1481 → 1564

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:499 → 550

Ank_4; Ankyrin repeats (many copies)
NM_001354266.2 → NP_001341195.1 ankyrin-2 isoform 33

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93583.1

UniProtKB/TrEMBL

A0A5F9ZHR2

Related

ENSP00000500527.1, ENST00000672955.1

Conserved Domains (6) summary

pfam06390
Location:1576 → 1733

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1420 → 1503

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:470 → 521

Ank_4; Ankyrin repeats (many copies)
NM_001354267.2 → NP_001341196.1 ankyrin-2 isoform 33

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93583.1

UniProtKB/TrEMBL

A0A5F9ZHR2

Related

ENSP00000500926.1, ENST00000671704.1

Conserved Domains (6) summary

pfam06390
Location:1576 → 1733

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1420 → 1503

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:470 → 521

Ank_4; Ankyrin repeats (many copies)
NM_001354268.2 → NP_001341197.1 ankyrin-2 isoform 35

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS93594.1

UniProtKB/TrEMBL

A0A5F9ZHE2

Related

ENSP00000500311.1, ENST00000672854.1

Conserved Domains (6) summary

pfam06390
Location:1572 → 1729

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:933 → 1037

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1416 → 1499

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:565 → 616

Ank_4; Ankyrin repeats (many copies)
NM_001354269.3 → NP_001341198.1 ankyrin-2 isoform 36

Status: REVIEWED

Source sequence(s)

AC004057, AC093900, AC106864

Conserved Domains (7) summary

pfam06390
Location:1567 → 1724

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:895 → 1032

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:10 → 92

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:223 → 348

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1411 → 1494

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:624 → 655

ANK; ANK repeat [structural motif]

pfam13637
Location:188 → 249

Ank_4; Ankyrin repeats (many copies)
NM_001354270.2 → NP_001341199.1 ankyrin-2 isoform 37

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93578.1

UniProtKB/TrEMBL

A0A5F9ZI08

Related

ENSP00000500843.1, ENST00000673546.1

Conserved Domains (6) summary

pfam06390
Location:1563 → 1720

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:924 → 1028

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1407 → 1490

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:544 → 595

Ank_4; Ankyrin repeats (many copies)
NM_001354271.2 → NP_001341200.1 ankyrin-2 isoform 38

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93587.1

UniProtKB/TrEMBL

A0A5F9ZHN0

Related

ENSP00000500528.1, ENST00000671951.1

Conserved Domains (6) summary

pfam06390
Location:1543 → 1700

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:904 → 1008

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1387 → 1470

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:536 → 587

Ank_4; Ankyrin repeats (many copies)
NM_001354272.2 → NP_001341201.1 ankyrin-2 isoform 39

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (6) summary

pfam06390
Location:1595 → 1752

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:956 → 1060

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1439 → 1522

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354273.2 → NP_001341202.1 ankyrin-2 isoform 40

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Conserved Domains (6) summary

pfam06390
Location:1538 → 1695

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:899 → 1003

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1382 → 1465

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:628 → 659

ANK; ANK repeat [structural motif]

pfam13637
Location:192 → 253

Ank_4; Ankyrin repeats (many copies)
NM_001354274.2 → NP_001341203.1 ankyrin-2 isoform 41

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93585.1

UniProtKB/TrEMBL

A0A5F9ZH58

Related

ENSP00000500112.1, ENST00000673453.1

Conserved Domains (6) summary

pfam06390
Location:1560 → 1697

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:932 → 1036

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:198 → 323

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1404 → 1487

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:470 → 521

Ank_4; Ankyrin repeats (many copies)
NM_001354275.2 → NP_001341204.1 ankyrin-2 isoform 42

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93576.1

UniProtKB/TrEMBL

A0A5F9ZHY6

Related

ENSP00000500712.1, ENST00000671756.1

Conserved Domains (6) summary

pfam06390
Location:1584 → 1741

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1049

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1428 → 1511

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:478 → 529

Ank_4; Ankyrin repeats (many copies)
NM_001354276.2 → NP_001341205.1 ankyrin-2 isoform 43

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93584.1

UniProtKB/TrEMBL

A0A5F9ZI53

Related

ENSP00000500908.1, ENST00000672731.1

Conserved Domains (9) summary

pfam06390
Location:1576 → 1733

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1420 → 1503

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001354277.2 → NP_001341206.1 ankyrin-2 isoform 44

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93588.1

UniProtKB/TrEMBL

A0A5F9ZH34

Related

ENSP00000499986.1, ENST00000671893.1

Conserved Domains (9) summary

pfam06390
Location:1510 → 1667

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:871 → 975

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02876
Location:219 → 559

PHA02876; ankyrin repeat protein; Provisional

PHA03095
Location:8 → 327

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1354 → 1437

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:599 → 630

ANK; ANK repeat [structural motif]

pfam13637
Location:666 → 718

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1196 → 1325

UPA_2; UPA domain

cl39094
Location:466 → 690

Ank_2; Ankyrin repeats (3 copies)
NM_001354278.2 → NP_001341207.1 ankyrin-2 isoform 45

Status: REVIEWED

Source sequence(s)

AC004057, AC093900

Consensus CDS

CCDS93600.1

UniProtKB/TrEMBL

A0A5F9ZH18, H0Y8Y2

Related

ENSP00000500007.1, ENST00000673353.1

Conserved Domains (3) summary

pfam06390
Location:814 → 971

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:175 → 279

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:658 → 741

Death_ank2; Death domain of Ankyrin-2
NM_001354279.2 → NP_001341208.1 ankyrin-2 isoform 46

Status: REVIEWED

Source sequence(s)

AC004057, AC093900

Consensus CDS

CCDS93597.1

UniProtKB/TrEMBL

A0A5F9ZH99, B7Z2H4

Related

ENSP00000500111.1, ENST00000673231.1

Conserved Domains (3) summary

pfam06390
Location:826 → 983

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:187 → 291

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:670 → 753

Death_ank2; Death domain of Ankyrin-2
NM_001354280.2 → NP_001341209.1 ankyrin-2 isoform 47

Status: REVIEWED

Source sequence(s)

AC004057, AC093900

Consensus CDS

CCDS93599.1

UniProtKB/TrEMBL

A0A5F9ZI16, B7Z2H4

Related

ENSP00000500832.1, ENST00000673048.1

Conserved Domains (3) summary

pfam06390
Location:821 → 978

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:175 → 279

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:665 → 748

Death_ank2; Death domain of Ankyrin-2
NM_001354281.2 → NP_001341210.1 ankyrin-2 isoform 48

Status: REVIEWED

Source sequence(s)

AC004057, AC093900

Consensus CDS

CCDS87250.1

UniProtKB/TrEMBL

B7Z2H4, E9PCH6

Related

ENSP00000426944.1, ENST00000509550.5

Conserved Domains (3) summary

pfam06390
Location:814 → 971

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:175 → 279

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:658 → 741

Death_ank2; Death domain of Ankyrin-2
NM_001354282.2 → NP_001341211.1 ankyrin-2 isoform 49

Status: REVIEWED

Source sequence(s)

AC004057, AC093900

Consensus CDS

CCDS93598.1

UniProtKB/TrEMBL

A0A5F9ZH10, B7Z2H4

Related

ENSP00000499979.1, ENST00000672411.1

Conserved Domains (3) summary

pfam06390
Location:826 → 983

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:187 → 291

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:670 → 753

Death_ank2; Death domain of Ankyrin-2
NM_001386142.1 → NP_001373071.1 ankyrin-2 isoform 50

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Related

ENSP00000500245.1, ENST00000673298.1

Conserved Domains (15) summary

pfam06390
Location:3645 → 3802

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:932 → 1036

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:1592 → 2036

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK14949
Location:3071 → 3317

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

cd08804
Location:3489 → 3572

Death_ank2; Death domain of Ankyrin-2

TIGR00600
Location:2906 → 3440

rad2; DNA excision repair protein (rad2)

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam15402
Location:2368 → 2509

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam17809
Location:1257 → 1386

UPA_2; UPA domain

NF033804
Location:1718 → 1902

Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

NF033838
Location:1424 → 1797

PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386143.1 → NP_001373072.1 ankyrin-2 isoform 51

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93572.1

UniProtKB/TrEMBL

A0A5F9ZGZ1

Related

ENSP00000499928.1, ENST00000671793.1

Conserved Domains (8) summary

pfam06390
Location:1617 → 1754

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:945 → 1082

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1461 → 1544

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1303 → 1432

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
NM_001386144.1 → NP_001373073.1 ankyrin-2 isoform 52

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (8) summary

pfam06390
Location:1653 → 1790

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:981 → 1118

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:419 → 704

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1497 → 1580

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:776 → 828

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1339 → 1468

UPA_2; UPA domain

cl39094
Location:576 → 800

Ank_2; Ankyrin repeats (3 copies)
NM_001386146.1 → NP_001373075.1 ankyrin-2 isoform 53

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1565 → 1702

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1409 → 1492

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386147.1 → NP_001373076.1 ankyrin-2 isoform 54

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093617, AC093900

Conserved Domains (9) summary

pfam06390
Location:1580 → 1737

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:952 → 1056

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:390 → 675

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:23 → 156

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1424 → 1507

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:416 → 447

ANK; ANK repeat [structural motif]

pfam13637
Location:747 → 799

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1277 → 1406

UPA_2; UPA domain

cl39094
Location:547 → 771

Ank_2; Ankyrin repeats (3 copies)
NM_001386148.2 → NP_001373077.1 ankyrin-2 isoform 55

Status: REVIEWED

Source sequence(s)

AC004057, AC093900, AC106864

Conserved Domains (8) summary

pfam06390
Location:1633 → 1790

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:961 → 1098

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:400 → 685

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1477 → 1560

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1319 → 1448

UPA_2; UPA domain

cl39094
Location:557 → 781

Ank_2; Ankyrin repeats (3 copies)
NM_001386149.1 → NP_001373078.1 ankyrin-2 isoform 56

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1565 → 1722

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1409 → 1492

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386150.1 → NP_001373079.1 ankyrin-2 isoform 57

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1565 → 1702

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1409 → 1492

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386151.1 → NP_001373080.1 ankyrin-2 isoform 58

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1543 → 1680

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:904 → 1008

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1387 → 1470

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:699 → 751

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1229 → 1358

UPA_2; UPA domain

pfam12796
Location:373 → 464

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:448 → 723

Ank_2; Ankyrin repeats (3 copies)
NM_001386152.1 → NP_001373081.1 ankyrin-2 isoform 59

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

UniProtKB/TrEMBL

A0A994J7V8

Conserved Domains (8) summary

pfam06390
Location:1657 → 1804

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:985 → 1122

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:419 → 704

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1501 → 1584

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:776 → 828

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1343 → 1472

UPA_2; UPA domain

cl39094
Location:576 → 800

Ank_2; Ankyrin repeats (3 copies)
NM_001386153.1 → NP_001373082.1 ankyrin-2 isoform 60

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1565 → 1722

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1409 → 1492

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386154.1 → NP_001373083.1 ankyrin-2 isoform 61

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1560 → 1717

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:932 → 1036

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1404 → 1487

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1257 → 1386

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386156.1 → NP_001373085.1 ankyrin-2 isoform 62

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93580.1

UniProtKB/TrEMBL

A0A5F9ZH03

Related

ENSP00000499943.1, ENST00000672684.1

Conserved Domains (8) summary

pfam06390
Location:1551 → 1708

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:912 → 1016

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:1395 → 1478

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:707 → 759

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1237 → 1366

UPA_2; UPA domain

pfam12796
Location:381 → 472

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:456 → 731

Ank_2; Ankyrin repeats (3 copies)
NM_001386157.1 → NP_001373086.1 ankyrin-2 isoform 63

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Related

ENSP00000499967.1, ENST00000672986.1

Conserved Domains (9) summary

pfam06390
Location:1510 → 1667

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:871 → 975

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02876
Location:219 → 559

PHA02876; ankyrin repeat protein; Provisional

PHA03095
Location:8 → 327

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1354 → 1437

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:599 → 630

ANK; ANK repeat [structural motif]

pfam13637
Location:666 → 718

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1196 → 1325

UPA_2; UPA domain

cl39094
Location:466 → 690

Ank_2; Ankyrin repeats (3 copies)
NM_001386158.1 → NP_001373087.1 ankyrin-2 isoform 64

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (9) summary

pfam06390
Location:1477 → 1634

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:838 → 942

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:114 → 432

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1321 → 1404

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:566 → 597

ANK; ANK repeat [structural motif]

pfam13637
Location:633 → 685

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1163 → 1292

UPA_2; UPA domain

pfam12796
Location:47 → 134

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:382 → 657

Ank_2; Ankyrin repeats (3 copies)
NM_001386160.1 → NP_001373089.1 ankyrin-2 isoform 71

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093617, AC093900

Conserved Domains (9) summary

pfam06390
Location:1586 → 1743

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:947 → 1051

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:390 → 675

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:23 → 156

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1430 → 1513

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:416 → 447

ANK; ANK repeat [structural motif]

pfam13637
Location:747 → 799

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1272 → 1401

UPA_2; UPA domain

cl39094
Location:547 → 771

Ank_2; Ankyrin repeats (3 copies)
NM_001386161.1 → NP_001373090.1 ankyrin-2 isoform 25

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Conserved Domains (8) summary

pfam06390
Location:1616 → 1773

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:944 → 1081

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1460 → 1543

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1302 → 1431

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
NM_001386162.1 → NP_001373091.1 ankyrin-2 isoform 43

Status: REVIEWED

Source sequence(s)

AC004057, AC017007, AC093900

Consensus CDS

CCDS93584.1

UniProtKB/TrEMBL

A0A5F9ZI53

Conserved Domains (9) summary

pfam06390
Location:1576 → 1733

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:937 → 1041

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:6 → 141

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1420 → 1503

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1262 → 1391

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
NM_001386166.1 → NP_001373095.1 ankyrin-2 isoform 65

Status: REVIEWED

Source sequence(s)

AC093900

Related

ENST00000683972.1

Conserved Domains (5) summary

PTZ00121
Location:333 → 960

PTZ00121; MAEBL; Provisional

PHA03307
Location:478 → 757

PHA03307; transcriptional regulator ICP4; Provisional

PRK14949
Location:1949 → 2195

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

cd08804
Location:2367 → 2450

Death_ank2; Death domain of Ankyrin-2

pfam17809
Location:124 → 253

UPA_2; UPA domain
NM_001386167.1 → NP_001373096.1 ankyrin-2 isoform 66

Status: REVIEWED

Source sequence(s)

AC093900

UniProtKB/TrEMBL

B7Z678

Conserved Domains (3) summary

pfam06390
Location:438 → 552

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

cd08804
Location:282 → 365

Death_ank2; Death domain of Ankyrin-2

pfam17809
Location:124 → 253

UPA_2; UPA domain
NM_001386174.1 → NP_001373103.1 ankyrin-2 isoform 67

Status: REVIEWED

Source sequence(s)

AC004057, AC093617, AC093900

Consensus CDS

CCDS93596.1

UniProtKB/TrEMBL

H0Y933

Related

ENSP00000422888.2, ENST00000506344.6

Conserved Domains (14) summary

pfam06390
Location:3770 → 3884

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:1013 → 1150

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:1717 → 2161

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:421 → 706

PHA03095; ankyrin-like protein; Provisional

PRK14949
Location:3196 → 3442

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

cd08804
Location:3614 → 3697

Death_ank2; Death domain of Ankyrin-2

TIGR00600
Location:3031 → 3565

rad2; DNA excision repair protein (rad2)

sd00045
Location:447 → 478

ANK; ANK repeat [structural motif]

pfam13637
Location:778 → 830

Ank_4; Ankyrin repeats (many copies)

pfam15402
Location:2493 → 2634

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam17809
Location:1371 → 1500

UPA_2; UPA domain

NF033804
Location:1843 → 2027

Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

NF033838
Location:1549 → 1922

PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form

cl39094
Location:578 → 802

Ank_2; Ankyrin repeats (3 copies)
NM_001386175.1 → NP_001373104.1 ankyrin-2 isoform 68

Status: REVIEWED

Source sequence(s)

AC004057, AC093617, AC093900

Conserved Domains (15) summary

pfam06390
Location:3762 → 3876

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:1005 → 1142

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:1709 → 2153

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:413 → 698

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:37 → 179

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK14949
Location:3188 → 3434

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

cd08804
Location:3606 → 3689

Death_ank2; Death domain of Ankyrin-2

TIGR00600
Location:3023 → 3557

rad2; DNA excision repair protein (rad2)

sd00045
Location:439 → 470

ANK; ANK repeat [structural motif]

pfam13637
Location:770 → 822

Ank_4; Ankyrin repeats (many copies)

pfam15402
Location:2485 → 2626

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam17809
Location:1363 → 1492

UPA_2; UPA domain

NF033804
Location:1835 → 2019

Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

NF033838
Location:1541 → 1914

PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form

cl39094
Location:570 → 794

Ank_2; Ankyrin repeats (3 copies)
NM_001386186.2 → NP_001373115.1 ankyrin-2 isoform 69

Status: REVIEWED

Source sequence(s)

AC004057, AC093900, AC106864

Conserved Domains (8) summary

pfam06390
Location:1633 → 1790

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:961 → 1098

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:400 → 685

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1477 → 1560

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1319 → 1448

UPA_2; UPA domain

cl39094
Location:557 → 781

Ank_2; Ankyrin repeats (3 copies)
NM_001386187.2 → NP_001373116.1 ankyrin-2 isoform 70

Status: REVIEWED

Source sequence(s)

AC004057, AC093900, AC106864

Conserved Domains (9) summary

pfam06390
Location:1593 → 1750

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:954 → 1058

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:392 → 677

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:25 → 158

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd08804
Location:1437 → 1520

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:418 → 449

ANK; ANK repeat [structural motif]

pfam13637
Location:749 → 801

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1279 → 1408

UPA_2; UPA domain

cl39094
Location:549 → 773

Ank_2; Ankyrin repeats (3 copies)
NM_020977.5 → NP_066187.2 ankyrin-2 isoform 2

See identical proteins and their annotated locations for NP_066187.2

Status: REVIEWED

Source sequence(s)

AC004057, AC093879, AC093900

Consensus CDS

CCDS43261.1

UniProtKB/Swiss-Prot

Q01484

Related

ENSP00000378044.3, ENST00000394537.7

Conserved Domains (8) summary

pfam06390
Location:1638 → 1795

NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

smart00218
Location:966 → 1103

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00248
Location:529 → 554

ANK; ankyrin repeats

cd00204
Location:227 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:1482 → 1565

Death_ank2; Death domain of Ankyrin-2

pfam12796
Location:237 → 328

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:37 → 84

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

112705622..113383736

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

116013980..116692458

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001386173.1: Suppressed sequence

Description

NM_001386173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.