U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Skap1 src kinase associated phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286975, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Skap1provided by RGD
Official Full Name
src kinase associated phosphoprotein 1provided by RGD
Primary source
RGD:708436
See related
EnsemblRapid:ENSRNOG00000023881 AllianceGenome:RGD:708436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scap1; Skap55
Summary
Enables SH2 domain binding activity. Predicted to be involved in several processes, including positive regulation of cell adhesion; positive regulation of immune response; and positive regulation of integrin activation. Predicted to act upstream of or within positive regulation of cell adhesion and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human SKAP1 (src kinase associated phosphoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 478.0), Spleen (RPKM 77.5) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Skap1 in Genome Data Viewer
Location:
10q26-q31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81921961..82229106)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81425472..81732651)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84309379..84619051)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095284 Neighboring gene uncharacterized LOC120095285 Neighboring gene homeo box B1 Neighboring gene uncharacterized LOC120095286 Neighboring gene uncharacterized LOC102551165 Neighboring gene uncharacterized LOC134480860 Neighboring gene sorting nexin 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. Wu L, et al. Mol Cell Biol, 2002 Apr. PMID 11909961, Free PMC Article
  2. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. Marie-Cardine A, et al. J Biol Chem, 1997 Jun 27. PMID 9195899
  3. Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. Cao D, et al. J Biol Chem, 2015 Sep 25. PMID 26242911, Free PMC Article
  4. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. Fujii Y, et al. FEBS Lett, 2003 Apr 10. PMID 12681493
  5. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Ménasché G, et al. Mol Cell Biol, 2007 Jun. PMID 17403904, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
src kinase-associated phosphoprotein 1
Names
SKAP-55
SKAP55 adapter protein
SKAP55 adaptor protein
pp55
src family-associated phosphoprotein 1
src kinase-associated phosphoprotein of 55 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173311.2 → NP_775433.2  src kinase-associated phosphoprotein 1

    See identical proteins and their annotated locations for NP_775433.2

    Status: PROVISIONAL

    Source sequence(s)
    BC097931
    UniProtKB/Swiss-Prot
    Q4V7G1, Q8CHI6
    UniProtKB/TrEMBL
    A0A8I5Y073, A6HIF5
    Related
    ENSRNOP00000033594.4, ENSRNOT00000030159.6
    Conserved Domains (3) summary
    cd12044
    Location:293 → 345
    SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
    cd13380
    Location:108 → 213
    PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:108 → 210
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    81921961..82229106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597053.3 → XP_017452542.1  src kinase-associated phosphoprotein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y073, A0A8I5ZTK3
    Related
    ENSRNOP00000080687.1, ENSRNOT00000095547.2

  2. XM_039085325.2 → XP_038941253.1  src kinase-associated phosphoprotein 1 isoform X2

    Conserved Domains (2) summary
    cd12044
    Location:130 → 182
    SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  3. XM_039085324.2 → XP_038941252.1  src kinase-associated phosphoprotein 1 isoform X2

    Conserved Domains (2) summary
    cd12044
    Location:130 → 182
    SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  4. XM_039085326.2 → XP_038941254.1  src kinase-associated phosphoprotein 1 isoform X2

    Conserved Domains (2) summary
    cd12044
    Location:130 → 182
    SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  5. XM_063268504.1 → XP_063124574.1  src kinase-associated phosphoprotein 1 isoform X2

  6. XM_039085327.2 → XP_038941255.1  src kinase-associated phosphoprotein 1 isoform X2

    Conserved Domains (2) summary
    cd12044
    Location:130 → 182
    SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7G1.1 GenPept UniProtKB/Swiss-Prot:Q4V7G1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools