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OR2V2 olfactory receptor family 2 subfamily V member 2 [ Homo sapiens (human) ]

Gene ID: 285659, updated on 2-Nov-2024

Summary

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Official Symbol
OR2V2provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily V member 2provided by HGNC
Primary source
HGNC:HGNC:15341
See related
Ensembl:ENSG00000182613 AllianceGenome:HGNC:15341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2V3; OST713
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR2V2 in Genome Data Viewer
Location:
5q35.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181147586..181159285)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181707607..181719306)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180574586..180586285)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 pseudogene Neighboring gene olfactory receptor family 2 subfamily V member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180556955-180557456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180565055-180565554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180574489-180575211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180577953-180578454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180586450-180587206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180587207-180587962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23778 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180588627-180588969 Neighboring gene Sharpr-MPRA regulatory region 11855 Neighboring gene tRNA-Val (anticodon AAC) 1-2 Neighboring gene tRNA-Leu (anticodon AAG) 7-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
  2. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 2V2
Names
olfactory receptor 2V3
olfactory receptor OR5-3
olfactory receptor, family 2, subfamily V, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206880.2 → NP_996763.1  olfactory receptor 2V2

    See identical proteins and their annotated locations for NP_996763.1

    Status: VALIDATED

    Source sequence(s)
    AC008620
    Consensus CDS
    CCDS4461.1
    UniProtKB/Swiss-Prot
    Q6IFL6, Q8NGV1, Q96R30
    UniProtKB/TrEMBL
    A0A126GVA3
    Related
    ENSP00000493207.1, ENST00000641492.1
    Conserved Domains (2) summary
    pfam00001
    Location:42 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34 → 306
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    181147586..181159285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181707607..181719306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96R30.3 GenPept UniProtKB/Swiss-Prot:Q96R30

Gene LinkOut

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