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ADGRD1 adhesion G protein-coupled receptor D1 [ Homo sapiens (human) ]

Gene ID: 283383, updated on 3-Nov-2024

Summary

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Official Symbol
ADGRD1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor D1provided by HGNC
Primary source
HGNC:HGNC:19893
See related
Ensembl:ENSG00000111452 MIM:613639; AllianceGenome:HGNC:19893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR25; GPR133
Summary
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]
Expression
Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues See more
Orthologs
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Genomic context

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See ADGRD1 in Genome Data Viewer
Location:
12q24.33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (130953907..131141469)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (130993251..131181371)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131438452..131626014)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:131355651-131356412 and GRCh37_chr12:131356413-131357174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7349 Neighboring gene Sharpr-MPRA regulatory region 1775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7351 Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7352 Neighboring gene RAN, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 4789 Neighboring gene uncharacterized LOC124903054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131464091-131465081 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25923 Neighboring gene ADGRD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7354 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:131495017-131496216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131512879-131513380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131532400-131532904 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:131542065-131542234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131555861-131556362 Neighboring gene uncharacterized LOC107984452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131616699-131617331 Neighboring gene long intergenic non-protein coding RNA 1257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131689145-131689646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7360 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:131707318-131707489 Neighboring gene uncharacterized LOC105370082 Neighboring gene Sharpr-MPRA regulatory region 713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131719246-131719855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131746328-131746828

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage. Sun JX, et al. Epigenetics, 2024 Dec. PMID 38564758, Free PMC Article
  2. ADGRD1 as a Potential Prognostic and Immunological Biomarker in Non-Small-Cell Lung Cancer. Lv M, et al. Biomed Res Int, 2022. PMID 36457341, Free PMC Article
  3. Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs. Tönjes A, et al. Hum Mol Genet, 2009 Dec 1. PMID 19729412, Free PMC Article
  4. N(6) -methyladenosine (m(6) A) RNA modification of G protein-coupled receptor 133 increases proliferation of lung adenocarcinoma. Wu G, et al. FEBS Open Bio, 2022 Mar. PMID 34185971, Free PMC Article
  5. Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133). Fischer L, et al. BMC Genomics, 2016 Aug 11. PMID 27516204, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.
    Title: Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.
  2. Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells.
    Title: Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells.
  3. Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage.
    Title: Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage.
  4. ADGRD1 as a Potential Prognostic and Immunological Biomarker in Non-Small-Cell Lung Cancer.
    Title: ADGRD1 as a Potential Prognostic and Immunological Biomarker in Non-Small-Cell Lung Cancer.
  5. N(6) -methyladenosine (m(6) A) RNA modification of G protein-coupled receptor 133 increases proliferation of lung adenocarcinoma.
    Title: N(6) -methyladenosine (m(6) A) RNA modification of G protein-coupled receptor 133 increases proliferation of lung adenocarcinoma.
  6. The results show that a broad spectrum of functionally relevant ADGRD1 variants is present in the human population which may cause clinically relevant phenotypes, while being compatible with life when heterozygous.
    Title: Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133).
  7. Cell adhesion receptor GPR133 couples to Gs protein
    Title: Cell adhesion receptor GPR133 couples to Gs protein.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. A role for GPR133 protein in affecting the length of the electrocardiographic RR interval and heart rate.
    Title: A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
EBI GWAS Catalog
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Joint influence of small-effect genetic variants on human longevity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of G protein-coupled receptor 133 (GPR133) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16770, MGC138512, MGC138514, DKFZp434B1272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G-protein coupled receptor D1
Names
G-protein coupled receptor 133
G-protein coupled receptor PGR25
probable G-protein coupled receptor 133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330497.2 → NP_001317426.1  adhesion G-protein coupled receptor D1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC078925, AK131538, AL162032, AY532280, BC112309, BC143775, BQ028954, DA520615, EU523118
    Consensus CDS
    CCDS81753.1
    UniProtKB/Swiss-Prot
    Q6QNK2
    UniProtKB/TrEMBL
    Q9NSM3
    Related
    ENSP00000444425.1, ENST00000535015.5

  2. NM_198827.5 → NP_942122.2  adhesion G-protein coupled receptor D1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_942122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC078925, AK131538, AL162032, AY532280, BC112307, BC112309, BQ028954, DA520615, EU523118
    Consensus CDS
    CCDS9272.1
    UniProtKB/Swiss-Prot
    B2CKK9, B7ZLF7, Q2M1L3, Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4
    Related
    ENSP00000261654.5, ENST00000261654.10
    Conserved Domains (3) summary
    pfam01825
    Location:510 → 550
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:138 → 241
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:566 → 802
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    130953907..131141469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538204.2 → XP_011536506.1  adhesion G-protein coupled receptor D1 isoform X1

    Conserved Domains (3) summary
    pfam01825
    Location:542 → 582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:598 → 834
    7tm_4; Olfactory receptor

  2. XM_011538206.2 → XP_011536508.1  adhesion G-protein coupled receptor D1 isoform X3

    Conserved Domains (3) summary
    pfam01825
    Location:542 → 582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:583 → 762
    7tm_4; Olfactory receptor

  3. XM_011538209.2 → XP_011536511.1  adhesion G-protein coupled receptor D1 isoform X8

    Conserved Domains (3) summary
    pfam01825
    Location:542 → 582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:590 → 666
    7tm_4; Olfactory receptor

  4. XM_011538205.2 → XP_011536507.1  adhesion G-protein coupled receptor D1 isoform X2

    Conserved Domains (3) summary
    pfam01825
    Location:482 → 522
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:139 → 213
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:538 → 774
    7tm_4; Olfactory receptor

  5. XM_011538208.2 → XP_011536510.1  adhesion G-protein coupled receptor D1 isoform X7

    Conserved Domains (2) summary
    pfam01825
    Location:397 → 437
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:453 → 689
    7tm_4; Olfactory receptor

  6. XM_005253566.2 → XP_005253623.1  adhesion G-protein coupled receptor D1 isoform X4

    Conserved Domains (3) summary
    pfam01825
    Location:450 → 490
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:107 → 181
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:506 → 742
    7tm_4; Olfactory receptor

  7. XM_047428719.1 → XP_047284675.1  adhesion G-protein coupled receptor D1 isoform X10

  8. XM_047428718.1 → XP_047284674.1  adhesion G-protein coupled receptor D1 isoform X9

  9. XM_011538207.2 → XP_011536509.1  adhesion G-protein coupled receptor D1 isoform X5

    Conserved Domains (3) summary
    pfam01825
    Location:542 → 582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:598 → 769
    7tm_4; Olfactory receptor

  10. XM_047428717.1 → XP_047284673.1  adhesion G-protein coupled receptor D1 isoform X6

  11. XM_011538210.3 → XP_011536512.1  adhesion G-protein coupled receptor D1 isoform X11

    Conserved Domains (2) summary
    pfam01825
    Location:542 → 582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily

  12. XM_047428720.1 → XP_047284676.1  adhesion G-protein coupled receptor D1 isoform X12

  13. XM_011538211.3 → XP_011536513.1  adhesion G-protein coupled receptor D1 isoform X13

    Conserved Domains (2) summary
    pfam01825
    Location:206 → 246
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:262 → 498
    7tm_4; Olfactory receptor

  14. XM_011538212.2 → XP_011536514.1  adhesion G-protein coupled receptor D1 isoform X14

    Related
    ENST00000376682.8
    Conserved Domains (2) summary
    pfam01825
    Location:132 → 172
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:188 → 424
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    130993251..131181371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371788.1 → XP_054227763.1  adhesion G-protein coupled receptor D1 isoform X1

  2. XM_054371790.1 → XP_054227765.1  adhesion G-protein coupled receptor D1 isoform X3

  3. XM_054371795.1 → XP_054227770.1  adhesion G-protein coupled receptor D1 isoform X8

  4. XM_054371789.1 → XP_054227764.1  adhesion G-protein coupled receptor D1 isoform X2

  5. XM_054371794.1 → XP_054227769.1  adhesion G-protein coupled receptor D1 isoform X7

  6. XM_054371791.1 → XP_054227766.1  adhesion G-protein coupled receptor D1 isoform X4

  7. XM_054371797.1 → XP_054227772.1  adhesion G-protein coupled receptor D1 isoform X10

  8. XM_054371796.1 → XP_054227771.1  adhesion G-protein coupled receptor D1 isoform X9

  9. XM_054371792.1 → XP_054227767.1  adhesion G-protein coupled receptor D1 isoform X5

  10. XM_054371793.1 → XP_054227768.1  adhesion G-protein coupled receptor D1 isoform X6

  11. XM_054371799.1 → XP_054227774.1  adhesion G-protein coupled receptor D1 isoform X12

  12. XM_054371798.1 → XP_054227773.1  adhesion G-protein coupled receptor D1 isoform X11

  13. XM_054371800.1 → XP_054227775.1  adhesion G-protein coupled receptor D1 isoform X13

  14. XM_054371801.1 → XP_054227776.1  adhesion G-protein coupled receptor D1 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QNK2.1 GenPept UniProtKB/Swiss-Prot:Q6QNK2

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