STK32C serine/threonine kinase 32C [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK32Cprovided by HGNC
Official Full Name: serine/threonine kinase 32Cprovided by HGNC
Primary source: HGNC:HGNC:21332
See related: Ensembl:ENSG00000165752 AllianceGenome:HGNC:21332
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKE; YANK3
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Broad expression in brain (RPKM 5.0), testis (RPKM 3.2) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (132207482..132332235, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (133150298..133274880, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (134020986..134145384, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of STK32C inhibited the activity of the HMGB1 pathway and regulated the expression of key genes in this pathway.
Title: Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression.
Observational study of gene-disease association. (HuGE Navigator)
Title: Replication of recently described type 2 diabetes gene variants in a South Indian population.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147730 (e-PCR)
- UniSTS:172865

AF021109 (e-PCR)
- UniSTS:44432

SHGC-153568 (e-PCR)
- UniSTS:177820

RH78525 (e-PCR)
- UniSTS:4793

HSC2HF042 (e-PCR)
- UniSTS:44482

SHGC-149165 (e-PCR)
- UniSTS:182236

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase 32C

Names: PKE protein kinase; testicular tissue protein Li 187; yet another novel kinase 3

NP_001305807.1

EC 2.7.11.1

NP_001305808.1

EC 2.7.11.1

NP_001305809.1

EC 2.7.11.1

NP_001305810.1

EC 2.7.11.1

NP_001305811.1

EC 2.7.11.1

NP_001305812.1

EC 2.7.11.1

NP_775846.2

EC 2.7.11.1

XP_011537990.1

EC 2.7.11.1

XP_011537992.1

EC 2.7.11.1

XP_011537995.1

EC 2.7.11.1

XP_011537996.1

EC 2.7.11.1

XP_011537997.1

EC 2.7.11.1

XP_016871589.1

EC 2.7.11.1

XP_016871590.1

EC 2.7.11.1

XP_024303715.2

EC 2.7.11.1

XP_024303717.2

EC 2.7.11.1

XP_047281068.1

EC 2.7.11.1

XP_047281069.1

EC 2.7.11.1

XP_047281070.1

EC 2.7.11.1

XP_047281071.1

EC 2.7.11.1

XP_054221615.1

EC 2.7.11.1

XP_054221616.1

EC 2.7.11.1

XP_054221617.1

EC 2.7.11.1

XP_054221618.1

EC 2.7.11.1

XP_054221619.1

EC 2.7.11.1

XP_054221620.1

EC 2.7.11.1

XP_054221621.1

EC 2.7.11.1

XP_054221622.1

EC 2.7.11.1

XP_054221623.1

EC 2.7.11.1

XP_054221624.1

EC 2.7.11.1

XP_054221625.1

EC 2.7.11.1

XP_054221626.1

EC 2.7.11.1

XP_054221627.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318878.2 → NP_001305807.1 serine/threonine-protein kinase 32C isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK302102, AL590105, CD369442, HY020713, HY070240

UniProtKB/TrEMBL

B7Z7J1, I6L972

Conserved Domains (2) summary

smart00220
Location:106 → 361

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05578
Location:105 → 366

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
NM_001318879.2 → NP_001305808.1 serine/threonine-protein kinase 32C isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AK302102, BC045760, CD369442, HY018020

Consensus CDS

CCDS81525.1

UniProtKB/TrEMBL

I6L972

Related

ENSP00000357611.1, ENST00000368622.5

Conserved Domains (1) summary

cd05578
Location:1 → 236

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
NM_001318880.2 → NP_001305809.1 serine/threonine-protein kinase 32C isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AA782619, AL590105, CD674243, HY020713, HY070240

Consensus CDS

CCDS81527.1

UniProtKB/TrEMBL

H0Y431

Related

ENSP00000389112.2, ENST00000456004.1
NM_001318881.2 → NP_001305810.1 serine/threonine-protein kinase 32C isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AL590105, AW770528, BE009030, BF508609, DA574949, HY020713

Consensus CDS

CCDS81526.1

UniProtKB/TrEMBL

H0Y349

Related

ENSP00000357608.4, ENST00000368619.3
NM_001318882.2 → NP_001305811.1 serine/threonine-protein kinase 32C isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AI911241, AL590105, BF508609, HY020713, HY106710, HY301367
NM_001318883.2 → NP_001305812.1 serine/threonine-protein kinase 32C isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon and lacks the remaining exons found in variant 1, but instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AL590105, BF449072, BF508609, HY020713
NM_173575.4 → NP_775846.2 serine/threonine-protein kinase 32C isoform b

See identical proteins and their annotated locations for NP_775846.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK302102, AY098866, CD369442

Consensus CDS

CCDS7666.1

UniProtKB/Swiss-Prot

Q5T0Q5, Q86UE1, Q86UX6

UniProtKB/TrEMBL

A0A140VJW0, I6L972

Related

ENSP00000298630.3, ENST00000298630.8

Conserved Domains (2) summary

smart00220
Location:93 → 348

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05578
Location:92 → 353

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

RNA

NR_134911.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains an alternate 5' terminal exon and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, which results in an ORF that is in-frame with the coding region of variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK057849, AK302102, BM749615, CD369442

Related

ENST00000462160.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

132207482..132332235 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011539693.3 → XP_011537995.1 serine/threonine-protein kinase 32C isoform X5

See identical proteins and their annotated locations for XP_011537995.1

UniProtKB/TrEMBL

I6L972

Conserved Domains (1) summary

cd05578
Location:1 → 236

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
XM_011539688.2 → XP_011537990.1 serine/threonine-protein kinase 32C isoform X1

Conserved Domains (2) summary

smart00220
Location:106 → 366

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05578
Location:105 → 371

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
XM_011539690.3 → XP_011537992.1 serine/threonine-protein kinase 32C isoform X2

UniProtKB/TrEMBL

I6L972

Conserved Domains (2) summary

smart00220
Location:93 → 353

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05578
Location:92 → 358

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
XM_011539695.2 → XP_011537997.1 serine/threonine-protein kinase 32C isoform X5

See identical proteins and their annotated locations for XP_011537997.1

UniProtKB/TrEMBL

I6L972

Conserved Domains (1) summary

cd05578
Location:1 → 236

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
XM_047425115.1 → XP_047281071.1 serine/threonine-protein kinase 32C isoform X5
XM_047425114.1 → XP_047281070.1 serine/threonine-protein kinase 32C isoform X6
XM_024447949.2 → XP_024303717.2 serine/threonine-protein kinase 32C isoform X7
XM_011539694.2 → XP_011537996.1 serine/threonine-protein kinase 32C isoform X5

See identical proteins and their annotated locations for XP_011537996.1

UniProtKB/TrEMBL

I6L972

Conserved Domains (1) summary

cd05578
Location:1 → 236

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
XM_047425113.1 → XP_047281069.1 serine/threonine-protein kinase 32C isoform X4
XM_047425112.1 → XP_047281068.1 serine/threonine-protein kinase 32C isoform X3
XM_024447947.2 → XP_024303715.2 serine/threonine-protein kinase 32C isoform X8

Related

ENSP00000357609.3, ENST00000368620.2
XM_017016101.2 → XP_016871590.1 serine/threonine-protein kinase 32C isoform X10
XM_017016100.2 → XP_016871589.1 serine/threonine-protein kinase 32C isoform X9