f10 coagulation factor X [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: f10provided by ZNC
Official Full Name: coagulation factor Xprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021206-9
See related: Ensembl:ENSDARG00000088581 AllianceGenome:ZFIN:ZDB-GENE-021206-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi12c10; wu:fi12c10
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including epidermis; liver; otic vesicle; pharyngeal arch; and yolk syncytial layer. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (136020..142173)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (136020..142173)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings as well as the prolonged survival of f10(-/-) mutants will enable us to expand our understanding of the molecular mechanisms of hemostasis, including a platform for screening variants of uncertain significance in patients with F10 deficiency and other coagulation disorders
Title: Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

fi12c10.x1 (e-PCR)
- UniSTS:204453

G45622 (e-PCR)
- UniSTS:106424

Z3766 (e-PCR)
- UniSTS:9691

Z3953 (e-PCR)
- UniSTS:19431

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coagulation factor X

Names: coagulation factor 10

NP_958870.3

EC 3.4.21.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201462.3 → NP_958870.3 coagulation factor X precursor

Status: VALIDATED

Source sequence(s)

FP017167

UniProtKB/TrEMBL

A0A8M1PG13, F1QLC3

Related

ENSDARP00000106731.1, ENSDART00000124837.3

Conserved Domains (5) summary

smart00020
Location:244 → 472

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:19 → 82

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:83 → 119

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:245 → 474

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:126 → 161

FXa_inhibition; Coagulation Factor Xa inhibitory site