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aldh3b1 aldehyde dehydrogenase 3 family, member B1 [ Danio rerio (zebrafish) ]

Gene ID: 282559, updated on 14-Nov-2024

Summary

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Official Symbol
aldh3b1provided by ZNC
Official Full Name
aldehyde dehydrogenase 3 family, member B1provided by ZNC
Primary source
ZFIN:ZDB-GENE-021120-3
See related
Ensembl:ENSDARG00000013839 AllianceGenome:ZFIN:ZDB-GENE-021120-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb508; aldh3d1; fb17d04; wu:fb17d04
Summary
Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be active in cytoplasm. Is expressed in EVL; ectoderm; epidermis; peripheral olfactory organ; and pharynx. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1) and ALDH3B2 (aldehyde dehydrogenase 3 family member B2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See aldh3b1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (34120233..34128952)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33990711..33999494)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-204f11.3 Neighboring gene immunoglobulin heavy variable 3-30 Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene si:dkey-204f11.64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. Holmes RS, et al. Chem Biol Interact, 2011 May 30. PMID 21296057
  2. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
  3. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article
  4. ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, et al. Cell Rep, 2024 Jul 23. PMID 38963759, Free PMC Article
  5. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Ma AC, et al. Leukemia, 2010 Dec. PMID 20927131

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 3 member B1
Names
aldehyde dehydrogenase 3 family, member D1
etID35986.3
NP_775328.2
XP_005164038.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173221.2 → NP_775328.2  aldehyde dehydrogenase family 3 member B1

    See identical proteins and their annotated locations for NP_775328.2

    Status: PROVISIONAL

    Source sequence(s)
    BC049338
    UniProtKB/TrEMBL
    Q7ZU10
    Related
    ENSDARP00000002746.5, ENSDART00000020017.7
    Conserved Domains (1) summary
    cd07132
    Location:5 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    34120233..34128952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163981.5 → XP_005164038.1  aldehyde dehydrogenase family 3 member B1 isoform X1

    See identical proteins and their annotated locations for XP_005164038.1

    UniProtKB/TrEMBL
    A0A286Y9L4, A0A8M2BB51, Q90ZZ7
    Related
    ENSDARP00000143864.2, ENSDART00000174929.2
    Conserved Domains (1) summary
    cd07132
    Location:5 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein
Heading Accession and Version

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