CSN1S2 casein alpha-S2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: CSN1S2
Gene description: casein alpha-S2
See related: BGD:BT25511; Ensembl:ENSBTAG00000005005
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (85530057..85548538)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Native disulphide-linked dimers facilitate amyloid fibril formation by bovine milk alphaS2-casein.
Title: Native disulphide-linked dimers facilitate amyloid fibril formation by bovine milk α(S2)-casein.
Identification of genomic regions associated with alphaS2-casein phosphorylation.
Title: Genome-wide association study for α(S1)- and α(S2)-casein phosphorylation in Dutch Holstein Friesian.
Translation attenuation via 3' terminal codon usage in bovine mRNA is responsible for the difference in alpha-S2- and beta-casein profile in milk.
Title: Translation attenuation via 3' terminal codon usage in bovine csn1s2 is responsible for the difference in αs2- and β-casein profile in milk.
Data indicate that the pepsin-pancreatin digest of alphaS-Casein exhibited anxiolytic-like activity.
Title: Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.
Alpha-S2-casein was less effective at preventing fibril formation by modified kappa-casein, whereas alpha- and alpha-S1 casein were comparably potent inhibitors.
Title: The chaperone action of bovine milk αS1- and αS2-caseins and their associated form αS-casein.
Substitution effects of paternal CSN2alpha(s1) allele versus CSN2alpha(s2) allele on protein yield deviations (YDs) are significant, whereas their effects on milk and fat YDs are not.
Title: Associations between 2 paternal casein haplotypes and milk yield traits of Swiss Fleckvieh cattle.
bovine milk alpha s2-casein readily forms fibrils in vitro. Upon incubation at neutral pH & 37 degrees C, spherical particles typical of alpha s2-casein rapidly converted to twisted, ribbon-like fibrils approximately 12 nm in diameter.
Title: Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.
study reports the SNP and AA change that distinguishes the B allele from other alleles at the CSN1S2 locus
Title: Molecular characterization of bovine CSN1S2*B and extensive distribution of zebu-specific milk protein alleles in European cattle.
Single strand conformation polymorphism (SSCP) is a particularly useful technique because it allows discrimination of alleles, including zebu-specific alleles at the CSN2 locus.
Title: High variability of milk protein genes in Bos indicus cattle breeds of Cameroon and Nigeria and characterization of a new alphas1-casein promoter allele.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zymogen binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alpha-S2-casein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174528.2 → NP_776953.1 alpha-S2-casein precursor

See identical proteins and their annotated locations for NP_776953.1

Status: PROVISIONAL

Source sequence(s)

M16644

UniProtKB/Swiss-Prot

P02663, Q1RMQ6, Q9TR51

Related

ENSBTAP00000006590.5, ENSBTAT00000006590.7

Conserved Domains (1) summary

pfam00363
Location:140 → 211

Casein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

Range

85530057..85548538

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024993017.2 → XP_024848785.1 alpha-S2-casein isoform X1

UniProtKB/Swiss-Prot

P02663, Q1RMQ6, Q9TR51

Conserved Domains (1) summary

pfam00363
Location:140 → 211

Casein