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ITGB1 integrin subunit beta 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281876, updated on 17-Aug-2024

Summary

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Official Symbol
ITGB1provided by VGNC
Official Full Name
integrin subunit beta 1provided by VGNC
Primary source
VGNC:VGNC:30324
See related
BGD:BT12510; Ensembl:ENSBTAG00000015910
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ITGB1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (19970709..20014499)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6C-like Neighboring gene uncharacterized LOC112449262 Neighboring gene coiled-coil domain containing 7 Neighboring gene vacuolar protein sorting-associated protein VTA1 homolog Neighboring gene ADP ribosylation factor like GTPase 5B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Galectin-3 contributes to luteolysis by binding to Beta 1 integrin in the bovine corpus luteum. Hashiba K, et al. Biol Reprod, 2014 Jul. PMID 24855102
  2. Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization. Radel C, et al. Am J Physiol Heart Circ Physiol, 2005 Feb. PMID 15471980
  3. Fibronectin receptors in preimplantation development: cloning, expression, and localization of the alpha 5 and beta 1 integrin subunits in bovine trophoblast. MacLaren LA, et al. Biol Reprod, 1995 Jul. PMID 7545439
  4. Expression and putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro. Thys M, et al. Reproduction, 2009 Sep. PMID 19505962
  5. Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses. Duque H, et al. J Virol, 2003 Feb. PMID 12551988, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overall findings suggest that the secreted galectin-3 stimulated by PGF plays a role in structural luteolysis by binding to beta 1 integrin.
    Title: Galectin-3 contributes to luteolysis by binding to Beta 1 integrin in the bovine corpus luteum.
  2. Putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.
    Title: Expression and putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.
  3. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
    Title: Matrix-specific suppression of integrin activation in shear stress signaling.
  4. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
    Title: TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
  5. integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myosin light chain diphosphorylation.
    Title: Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization.
  6. both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound
    Title: A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC137337

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-X3-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables collagen binding involved in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-1
Names
VLA-4 subunit beta
fibronectin receptor subunit beta
integrin VLA-4 subunit beta
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174368.3 → NP_776793.1  integrin beta-1 precursor

    See identical proteins and their annotated locations for NP_776793.1

    Status: PROVISIONAL

    Source sequence(s)
    AF468058
    UniProtKB/TrEMBL
    A0A452DIS2
    Conserved Domains (3) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    19970709..20014499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000308.2 → XP_024856076.1  integrin beta-1 isoform X2

    UniProtKB/Swiss-Prot
    P53712, Q0PDN7, Q29RM8, Q8SQC0
    UniProtKB/TrEMBL
    A0A452DIS2
    Conserved Domains (3) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain

  2. XM_025000309.2 → XP_024856077.1  integrin beta-1 isoform X2

    UniProtKB/Swiss-Prot
    P53712, Q0PDN7, Q29RM8, Q8SQC0
    UniProtKB/TrEMBL
    A0A452DIS2
    Related
    ENSBTAP00000021156.6, ENSBTAT00000021156.7
    Conserved Domains (3) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain

  3. XM_005214148.5 → XP_005214205.1  integrin beta-1 isoform X1

    See identical proteins and their annotated locations for XP_005214205.1

    UniProtKB/TrEMBL
    A0A140T8D2, A0A452DIS2
    Related
    ENSBTAP00000052015.3, ENSBTAT00000056716.3
    Conserved Domains (3) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 796
    Integrin_b_cyt; Integrin beta cytoplasmic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53712.3 GenPept UniProtKB/Swiss-Prot:P53712

Gene LinkOut

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Molecular Biology Databases
Research Materials