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ITGAV integrin subunit alpha V [ Bos taurus (domestic cattle) ]

Gene ID: 281875, updated on 4-Oct-2024

Summary

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Official Symbol
ITGAVprovided by VGNC
Official Full Name
integrin subunit alpha Vprovided by VGNC
Primary source
VGNC:VGNC:30323
See related
BGD:BT24336; Ensembl:ENSBTAG00000019929
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ITGAV in Genome Data Viewer
Location:
chromosome: 2
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (9640553..9749414, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 2 Neighboring gene family with sequence similarity 171 member B Neighboring gene microRNA mir-2351 Neighboring gene small integral membrane protein 20-like Neighboring gene uncharacterized LOC132342943 Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit. Neff S, et al. J Virol, 2000 Aug. PMID 10906183, Free PMC Article
  2. Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness. Dicara D, et al. J Virol, 2008 Feb. PMID 18045932, Free PMC Article
  3. Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains. Andersen MH, et al. Biochemistry, 1997 May 6. PMID 9154926
  4. Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability. Ganter MT, et al. Am J Respir Cell Mol Biol, 2009 Jan. PMID 18703797, Free PMC Article
  5. Interactions of foot-and-mouth disease virus with soluble bovine alphaVbeta3 and alphaVbeta6 integrins. Duque H, et al. J Virol, 2004 Sep. PMID 15331710, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
    Title: Matrix-specific suppression of integrin activation in shear stress signaling.
  2. These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
    Title: Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability.
  3. specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.
    Title: Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness.
  4. identified as receptor for foot-and-mouth disease virus
    Title: Interactions of foot-and-mouth disease virus with soluble bovine alphaVbeta3 and alphaVbeta6 integrins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC159480

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-V
Names
integrin alpha V subunit
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
vitronectin receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174367.1 → NP_776792.1  integrin alpha-V precursor

    See identical proteins and their annotated locations for NP_776792.1

    Status: PROVISIONAL

    Source sequence(s)
    AF239958
    UniProtKB/Swiss-Prot
    P80746, Q0PDN6, Q9GK48, Q9MZD6
    Related
    ENSBTAP00000083933.1, ENSBTAT00000092224.1
    Conserved Domains (4) summary
    smart00191
    Location:366 → 420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:466 → 913
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:220 → 270
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    sd00039
    Location:51 → 119
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    9640553..9749414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202252.5 → XP_005202309.1  integrin alpha-V isoform X1

    UniProtKB/Swiss-Prot
    P80746, Q0PDN6, Q9GK48, Q9MZD6
    UniProtKB/TrEMBL
    A0A3Q1MXS2, A0AAA9SEW0
    Related
    ENSBTAP00000060618.1, ENSBTAT00000082026.2
    Conserved Domains (4) summary
    smart00191
    Location:367 → 421
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:467 → 914
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:221 → 271
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    sd00039
    Location:51 → 120
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80746.3 GenPept UniProtKB/Swiss-Prot:P80746

Gene LinkOut

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