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TGM2 transglutaminase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281528, updated on 4-Oct-2024

Summary

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Official Symbol
TGM2provided by VGNC
Official Full Name
transglutaminase 2provided by VGNC
Primary source
VGNC:VGNC:35810
See related
BGD:BT15293; Ensembl:ENSBTAG00000016208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TG
Orthologs
human mouse all
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Genomic context

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See TGM2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (67002550..67037025, complement)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene TELO2 interacting protein 1 Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC104973875 Neighboring gene KIAA1755

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol, 2014 Oct 1. PMID 25128524, Free PMC Article
  2. Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties. Kaartinen MT, et al. J Biol Chem, 1999 Jan 15. PMID 9880554
  3. Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase. Nara K, et al. J Biol Chem, 1989 Nov 15. PMID 2572599
  4. Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase. Nakanishi K, et al. Eur J Biochem, 1991 Nov 15. PMID 1682150
  5. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. Johnson KA, et al. J Biol Chem, 2005 Apr 15. PMID 15691824

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
    Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
  2. An important role for TG2, mediated by intracellular calcium fluxes and HIF1A, in hypoxia-induced pulmonary artery smooth muscle cells proliferation.
    Title: Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
  3. externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding
    Title: External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein-glutamine gamma-glutamyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide cross-linking IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase 2
Names
TG(C)
TGC
TGase C
TGase-2
isopeptidase TGM2
protein-glutamine deamidase TGM2
protein-glutamine dopaminyltransferase TGM2
protein-glutamine histaminyltransferase TGM2
protein-glutamine noradrenalinyltransferase TGM2
protein-glutamine serotonyltransferase TGM2
tissue transglutaminase
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
transglutaminase C
NP_803473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177507.2 → NP_803473.1  protein-glutamine gamma-glutamyltransferase 2

    See identical proteins and their annotated locations for NP_803473.1

    Status: PROVISIONAL

    Source sequence(s)
    X60686
    UniProtKB/Swiss-Prot
    P51176, Q3ZBH7
    UniProtKB/TrEMBL
    A0A140T892
    Related
    ENSBTAP00000068864.2, ENSBTAT00000074363.2
    Conserved Domains (4) summary
    smart00460
    Location:269 → 361
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:271 → 369
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:6 → 120
    Transglut_N; Transglutaminase family
    pfam00927
    Location:587 → 686
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    67002550..67037025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51176.1 GenPept UniProtKB/Swiss-Prot:P51176

Gene LinkOut

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