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MAP2 microtubule associated protein 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281294, updated on 17-Aug-2024

Summary

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Official Symbol
MAP2provided by VGNC
Official Full Name
microtubule associated protein 2provided by VGNC
Primary source
VGNC:VGNC:31182
See related
BGD:BT21488; Ensembl:ENSBTAG00000018130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MAP2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (97263457..97562142)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene protein salvador homolog 1-like Neighboring gene uncharacterized LOC132343579 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1 like Neighboring gene ribulose-5-phosphate-3-epimerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring the microtubule-binding region of bovine microtubule-associated protein-2 (MAP-2): cDNA sequencing, bacterial expression, and site-directed mutagenesis. Coffey RL, et al. Biochemistry, 1994 Nov 15. PMID 7947727
  2. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. Sontag JM, et al. J Biol Chem, 2012 Apr 27. PMID 22403409, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
    Title: The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated protein 2
Names
microtubule associated protein 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205807.1 → NP_001192736.1  microtubule-associated protein 2

    See identical proteins and their annotated locations for NP_001192736.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000002
    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1701 → 1730
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1515
    MAP2_projctn; MAP2/Tau projection domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    97263457..97562142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010802225.4 → XP_010800527.1  microtubule-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_010800527.1

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  2. XM_024998329.2 → XP_024854097.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  3. XM_024998302.2 → XP_024854070.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  4. XM_005202699.5 → XP_005202756.1  microtubule-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005202756.1

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  5. XM_010802230.4 → XP_010800532.1  microtubule-associated protein 2 isoform X5

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  6. XM_010802231.4 → XP_010800533.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1785 → 1814
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  7. XM_010802234.4 → XP_010800536.1  microtubule-associated protein 2 isoform X9

    UniProtKB/TrEMBL
    F1MEW3
    Related
    ENSBTAP00000024134.6, ENSBTAT00000024134.6
    Conserved Domains (2) summary
    pfam00418
    Location:1785 → 1814
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  8. XM_010802228.4 → XP_010800530.1  microtubule-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1841 → 1870
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  9. XM_010802232.4 → XP_010800534.1  microtubule-associated protein 2 isoform X7

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1784 → 1813
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  10. XM_059891367.1 → XP_059747350.1  microtubule-associated protein 2 isoform X11

    UniProtKB/TrEMBL
    F1MEW3

  11. XM_015458760.3 → XP_015314246.1  microtubule-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1841 → 1870
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1598
    MAP2_projctn; MAP2/Tau projection domain

  12. XM_059891372.1 → XP_059747355.1  microtubule-associated protein 2 isoform X12

    UniProtKB/TrEMBL
    F1MEW3

  13. XM_024998376.2 → XP_024854144.1  microtubule-associated protein 2 isoform X13

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1783 → 1812
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1598
    MAP2_projctn; MAP2/Tau projection domain

  14. XM_010802233.4 → XP_010800535.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1758 → 1787
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1515
    MAP2_projctn; MAP2/Tau projection domain

  15. XM_024998381.2 → XP_024854149.1  microtubule-associated protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A3Q1NAK9, F1MEW3
    Related
    ENSBTAP00000068316.2, ENSBTAT00000071341.2
    Conserved Domains (2) summary
    pfam00418
    Location:1701 → 1730
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1515
    MAP2_projctn; MAP2/Tau projection domain

  16. XM_059891386.1 → XP_059747369.1  microtubule-associated protein 2 isoform X17

    UniProtKB/TrEMBL
    F1MEW3

  17. XM_059891385.1 → XP_059747368.1  microtubule-associated protein 2 isoform X16

    UniProtKB/TrEMBL
    F1MEW3

  18. XM_059891380.1 → XP_059747363.1  microtubule-associated protein 2 isoform X15

    UniProtKB/TrEMBL
    F1MEW3

  19. XM_010802237.4 → XP_010800539.1  microtubule-associated protein 2 isoform X19

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1697 → 1726
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1511
    MAP2_projctn; MAP2/Tau projection domain

  20. XM_059891396.1 → XP_059747379.1  microtubule-associated protein 2 isoform X21

    UniProtKB/TrEMBL
    F1MEW3

  21. XM_059891392.1 → XP_059747375.1  microtubule-associated protein 2 isoform X20

    UniProtKB/TrEMBL
    F1MEW3

  22. XM_010802238.4 → XP_010800540.1  microtubule-associated protein 2 isoform X23

    See identical proteins and their annotated locations for XP_010800540.1

    UniProtKB/TrEMBL
    A0A3Q1MQE4
    Related
    ENSBTAP00000071956.1, ENSBTAT00000080758.2
    Conserved Domains (2) summary
    pfam00418
    Location:392 → 421
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl25751
    Location:108 → 388
    DUF4045; Domain of unknown function (DUF4045)

  23. XM_059891412.1 → XP_059747395.1  microtubule-associated protein 2 isoform X25

  24. XM_010802240.4 → XP_010800542.1  microtubule-associated protein 2 isoform X26

    See identical proteins and their annotated locations for XP_010800542.1

    Conserved Domains (2) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl25751
    Location:110 → 300
    DUF4045; Domain of unknown function (DUF4045)

  25. XM_010802241.4 → XP_010800543.1  microtubule-associated protein 2 isoform X27

    See identical proteins and their annotated locations for XP_010800543.1

    Conserved Domains (2) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl25751
    Location:110 → 300
    DUF4045; Domain of unknown function (DUF4045)

  26. XM_059891409.1 → XP_059747392.1  microtubule-associated protein 2 isoform X24

  27. XM_059891418.1 → XP_059747401.1  microtubule-associated protein 2 isoform X28

  28. XM_024998347.2 → XP_024854115.1  microtubule-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1841 → 1870
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:460 → 1598
    MAP2_projctn; MAP2/Tau projection domain

  29. XM_059891435.1 → XP_059747418.1  microtubule-associated protein 2 isoform X32

    UniProtKB/TrEMBL
    F1MEW3

  30. XM_059891431.1 → XP_059747414.1  microtubule-associated protein 2 isoform X31

    UniProtKB/TrEMBL
    F1MEW3

  31. XM_059891388.1 → XP_059747371.1  microtubule-associated protein 2 isoform X18

    UniProtKB/TrEMBL
    F1MEW3

  32. XM_059891405.1 → XP_059747388.1  microtubule-associated protein 2 isoform X22

    UniProtKB/TrEMBL
    F1MEW3

  33. XM_059891424.1 → XP_059747407.1  microtubule-associated protein 2 isoform X29

  34. XM_059891429.1 → XP_059747412.1  microtubule-associated protein 2 isoform X30

  35. XM_059891337.1 → XP_059747320.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    F1MEW3

  36. XM_059891324.1 → XP_059747307.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    F1MEW3

  37. XM_005202698.5 → XP_005202755.1  microtubule-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005202755.1

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1842 → 1871
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:461 → 1599
    MAP2_projctn; MAP2/Tau projection domain

  38. XM_059891355.1 → XP_059747338.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MEW3

  39. XM_059891365.1 → XP_059747348.1  microtubule-associated protein 2 isoform X10

    UniProtKB/TrEMBL
    F1MEW3

  40. XM_024998369.2 → XP_024854137.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1758 → 1787
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1515
    MAP2_projctn; MAP2/Tau projection domain

  41. XM_024998373.2 → XP_024854141.1  microtubule-associated protein 2 isoform X10

    UniProtKB/TrEMBL
    F1MEW3
    Conserved Domains (2) summary
    pfam00418
    Location:1754 → 1783
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1511
    MAP2_projctn; MAP2/Tau projection domain

  42. XM_024998388.2 → XP_024854156.1  microtubule-associated protein 2 isoform X26

    Conserved Domains (2) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl25751
    Location:110 → 300
    DUF4045; Domain of unknown function (DUF4045)

  43. XM_024998393.2 → XP_024854161.1  microtubule-associated protein 2 isoform X27

    Conserved Domains (2) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl25751
    Location:110 → 300
    DUF4045; Domain of unknown function (DUF4045)
Nucleotide Protein Strain
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