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KRT8 keratin 8 [ Bos taurus (domestic cattle) ]

Gene ID: 281269, updated on 4-Oct-2024

Summary

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Official Symbol
KRT8provided by VGNC
Official Full Name
keratin 8provided by VGNC
Primary source
VGNC:VGNC:50407
See related
Ensembl:ENSBTAG00000000836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
KRT2-8
Orthologs
human mouse all
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Genomic context

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See KRT8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (27040267..27047717)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene keratin 18 Neighboring gene uncharacterized LOC104976949 Neighboring gene uncharacterized LOC132345257 Neighboring gene keratin 78

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytokeratin expression in simple epithelia. II. cDNA cloning and sequence characteristics of bovine cytokeratin A (no. 8). Magin TM, et al. Differentiation, 1986. PMID 2422084
  2. Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines. Duncan A, et al. Reprod Biol Endocrinol, 2012 Oct 31. PMID 23113883, Free PMC Article
  3. Effects of Intrauterine Growth Restriction During Late Pregnancy on the Development of the Ovine Fetal Thymus and the T-Lymphocyte Subpopulation. Liu Y, et al. Am J Reprod Immunol, 2015 Jul. PMID 25708257
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells.
    Title: Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
keratin, type II cytoskeletal 8
Names
CK-8
K8
KERA
cytokeratin 8
cytokeratin-A
type-II keratin Kb8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033610.1 → NP_001028782.1  keratin, type II cytoskeletal 8

    See identical proteins and their annotated locations for NP_001028782.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103339
    UniProtKB/Swiss-Prot
    P05786, Q3SYX7
    UniProtKB/TrEMBL
    F1MU12
    Related
    ENSBTAP00000001108.6, ENSBTAT00000001108.7
    Conserved Domains (4) summary
    pfam00038
    Location:97 → 408
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 63
    Filament_head; Intermediate filament head (DNA binding) region
    pfam16208
    Location:18 → 94
    Keratin_2_head; Keratin type II head
    cl23720
    Location:308 → 377
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27040267..27047717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05786.3 GenPept UniProtKB/Swiss-Prot:P05786

Gene LinkOut

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