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GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Bos taurus (domestic cattle) ]

Gene ID: 281183, updated on 10-Oct-2024

Summary

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Official Symbol
GARTprovided by VGNC
Official Full Name
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by VGNC
Primary source
VGNC:VGNC:29255
See related
BGD:BT23672; Ensembl:ENSBTAG00000009188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GART in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (1985253..2012391)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene SON DNA and RNA binding protein Neighboring gene microRNA mir-6501 Neighboring gene uncharacterized LOC104970777 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2. Fritz S, et al. PLoS One, 2013. PMID 23762392, Free PMC Article
  2. Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2. Wöhlke A, et al. Gene, 2005 Mar 28. PMID 15777723
  3. Mapping of the bovine genes of the de novo AMP synthesis pathway. Bønsdorff T, et al. Anim Genet, 2004 Dec. PMID 15566465
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
    Title: Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC137968

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoribosylamine-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
trifunctional purine biosynthetic protein adenosine-3
Names
glycinamide ribonucleotide synthetase
phosphoribosylglycinamide synthetase
NP_001035563.1
XP_059741795.1
XP_059741826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040473.2 → NP_001035563.1  trifunctional purine biosynthetic protein adenosine-3

    See identical proteins and their annotated locations for NP_001035563.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122573
    UniProtKB/Swiss-Prot
    Q59A32
    UniProtKB/TrEMBL
    A0AAA9SDW8
    Related
    ENSBTAP00000012108.3, ENSBTAT00000012108.5
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    1985253..2012391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059885812.1 → XP_059741795.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    Q59A32

  2. XM_059885843.1 → XP_059741826.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    Q59A32
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q59A32.1 GenPept UniProtKB/Swiss-Prot:Q59A32

Gene LinkOut

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