OXT oxytocin/neurophysin I prepropeptide [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: OXTprovided by VGNC
Official Full Name: oxytocin/neurophysin I prepropeptideprovided by VGNC
Primary source: VGNC:VGNC:32515
See related: BGD:BT10314; Ensembl:ENSBTAG00000008026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: OTNPI; OT-NPI
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (52113982..52114880, complement)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
Title: Interrelationships between ovarian follicles grown in culture and possible mediators.
Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle.
Title: Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy.
These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary
Title: Effect of cortisol on neurophysin I/oxytocin and peptidyl glycine-alpha-amidating mono-oxygenase mRNA expression in bovine luteal and granulosa cells.
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum.
Title: Positive association, in local release, of luteal oxytocin with endothelin 1 and prostaglandin F2alpha during spontaneous luteolysis in the cow: a possible intermediatory role for luteolytic cascade within the corpus luteum.
data demonstrate an effect of dimerization in the unliganded state on the hormone-binding site involving residues that interact with hormone residue 2, & identify Ser25 & Ile26 as likely intermediaries between the sites of dimerization & hormone binding
Title: NMR investigation of main-chain dynamics of the H80E mutant of bovine neurophysin-I: demonstration of dimerization-induced changes at the hormone-binding site.
Binding of oestrogen receptor-related receptor alpha to the oxytocin promoter binding site is demonstrated, suggesting the involvement of this receptor in oestrogen-dependent up-regulation.
Title: Transcriptional activation of the oxytocin promoter by oestrogens uses a novel non-classical mechanism of oestrogen receptor action.
loop status modulates dimerization via long-range effects on neurophysin conformation involving neighboring Phe22 as a key intermediary
Title: Contributions of the interdomain loop, amino terminus, and subunit interface to the ligand-facilitated dimerization of neurophysin: crystal structures and mutation studies of bovine neurophysin-I.

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General gene information

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Markers

OXT (e-PCR)
- UniSTS:253719

OXT-1 (e-PCR)
- UniSTS:253719

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables neurohypophyseal hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: oxytocin-neurophysin 1

Names: oxytocin, prepro- (neurophysin I); oxytocin, prepropeptide; prepro-oxytocin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.