CD46 CD46 molecule [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: CD46
Gene description: CD46 molecule
See related: BGD:BT12887; Ensembl:ENSBTAG00000005397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MCP
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Genomic context

Location:: chromosome: 16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (75582021..75621087, complement)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Different impact of bovine complement regulatory protein 46 (CD46bov) as a cellular receptor for members of the species Pestivirus H and Pestivirus G.
Title: Different impact of bovine complement regulatory protein 46 (CD46(bov)) as a cellular receptor for members of the species Pestivirus H and Pestivirus G.
study found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood; also detected high- and low-sCD46 performers and show that this phenotype does not depend of environmen.
Title: Soluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus.
Study shows the existence of 10 distinct allelic versions of the CCP1 module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.
Title: Genetic and splice variations of Bos taurus CD46 shift cell permissivity to BVDV, the bovine pestivirus.
localization of CD46 on bovine sperm membrane
Title: Comparative fluorescence analysis of the bovine sperm using IVA-520 (anti-CD46 antibody) and lectins: probable localisation of CD46 on bovine sperm membrane.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in negative regulation of complement activation, classical pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: membrane cofactor protein

Names: CD46 molecule, complement regulatory protein; brain microvascular membrane cofactor; complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242561.2 → NP_001229490.2 membrane cofactor protein isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

NKLS02000016

UniProtKB/TrEMBL

A0A075TEJ1
NM_001242562.2 → NP_001229491.2 membrane cofactor protein isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three consecutive in-frame exons in the coding region, compared to variant 4. The resulting isoform (3) lacks an internal segment, compared to isoform 4.

Source sequence(s)

NKLS02000016

UniProtKB/TrEMBL

A0A060IHZ1
NM_001242563.2 → NP_001229492.2 membrane cofactor protein isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks three consecutive in-frame exons in the middle region and has an additional exon in the 3' region, compared to variant 4. The resulting isoform (1) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 4.

Source sequence(s)

NKLS02000016

UniProtKB/TrEMBL

F6K7I7

Related

ENSBTAP00000068115.1, ENSBTAT00000076400.2
NM_001242564.1 → NP_001229493.1 membrane cofactor protein isoform 6 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks three consecutive in-frame exons in the coding region, and has an alternate 3' exon, compared to variant 4. The resulting isoform (6) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 4.

Source sequence(s)

AY333119, BC149005, HM449689

UniProtKB/TrEMBL

F6K7J2

Conserved Domains (3) summary

cd00033
Location:171 → 233

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:43 → 294

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:237 → 292

Sushi; Sushi repeat (SCR repeat)
NM_001242565.1 → NP_001229494.1 membrane cofactor protein isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks three consecutive in-frame exons and a 4nt segment, and has an alternate 3' exons, compared to variant 4. The resulting isoform (5) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 4.

Source sequence(s)

BC149005, HM449684

UniProtKB/TrEMBL

A6QNU3

Conserved Domains (3) summary

cd00033
Location:171 → 233

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:43 → 294

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:237 → 292

Sushi; Sushi repeat (SCR repeat)
NM_183080.3 → NP_898903.3 membrane cofactor protein isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks three consecutive in-frame exons and a 4nt segment in the coding region, compared to variant 4. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 4.

Source sequence(s)

NKLS02000016

UniProtKB/TrEMBL

A0A060IE95, A0A060INZ0, F6K7I8

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

Range

75582021..75621087 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024975992.2 → XP_024831760.1 membrane cofactor protein isoform X15

UniProtKB/TrEMBL

A0A060IE95, A0A060INZ0, F6K7I8

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217321.5 → XP_005217378.2 membrane cofactor protein isoform X13

UniProtKB/TrEMBL

A0A060IHZ1

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_010813538.4 → XP_010811840.2 membrane cofactor protein isoform X12

UniProtKB/TrEMBL

A0A060IHZ1, A0A3Q1N570

Related

ENSBTAP00000065225.2, ENSBTAT00000073079.2

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217319.5 → XP_005217376.2 membrane cofactor protein isoform X9

UniProtKB/TrEMBL

A0A075TEJ1

Related

ENSBTAP00000054031.3, ENSBTAT00000065728.3

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217313.5 → XP_005217370.2 membrane cofactor protein isoform X5

UniProtKB/TrEMBL

F6K7J1

Conserved Domains (2) summary

pfam05399
Location:280 → 389

EVI2A; Ectropic viral integration site 2A protein (EVI2A)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217312.5 → XP_005217369.2 membrane cofactor protein isoform X4

UniProtKB/TrEMBL

A0A075TEJ1

Conserved Domains (2) summary

cl27167
Location:310 → 381

HemX; putative uroporphyrinogen-III C-methyltransferase

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217310.5 → XP_005217367.2 membrane cofactor protein isoform X2

UniProtKB/TrEMBL

F6K7J1

Conserved Domains (2) summary

cl25496
Location:295 → 374

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217309.5 → XP_005217366.2 membrane cofactor protein isoform X1

UniProtKB/TrEMBL

A0A075TEJ1

Conserved Domains (2) summary

cl25751
Location:284 → 372

DUF4045; Domain of unknown function (DUF4045)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_059875211.1 → XP_059731194.1 membrane cofactor protein isoform X14
XM_059875213.1 → XP_059731196.1 membrane cofactor protein isoform X19
XM_059875212.1 → XP_059731195.1 membrane cofactor protein isoform X18
XM_005217324.5 → XP_005217381.2 membrane cofactor protein isoform X17

UniProtKB/TrEMBL

A6QNU3

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217323.5 → XP_005217380.2 membrane cofactor protein isoform X16

UniProtKB/TrEMBL

F6K7J2

Conserved Domains (1) summary

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_024975987.2 → XP_024831755.1 membrane cofactor protein isoform X10

UniProtKB/TrEMBL

A0A3Q1MT36

Conserved Domains (2) summary

cl27167
Location:310 → 381

HemX; putative uroporphyrinogen-III C-methyltransferase

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217317.5 → XP_005217374.2 membrane cofactor protein isoform X8

UniProtKB/TrEMBL

F6K7J1

Conserved Domains (2) summary

cl25751
Location:284 → 372

DUF4045; Domain of unknown function (DUF4045)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_024975981.2 → XP_024831749.1 membrane cofactor protein isoform X3

UniProtKB/TrEMBL

A0A3Q1M3Z1, A0A3Q1MT36

Related

ENSBTAP00000062932.2, ENSBTAT00000086249.2

Conserved Domains (2) summary

cl25496
Location:295 → 374

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217314.5 → XP_005217371.2 membrane cofactor protein isoform X6

UniProtKB/TrEMBL

A0A3Q1MT36

Conserved Domains (2) summary

cl25496
Location:299 → 374

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217320.5 → XP_005217377.2 membrane cofactor protein isoform X11

UniProtKB/TrEMBL

F6K7J1

Conserved Domains (2) summary

pfam05399
Location:280 → 389

EVI2A; Ectropic viral integration site 2A protein (EVI2A)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_005217316.5 → XP_005217373.2 membrane cofactor protein isoform X7

UniProtKB/TrEMBL

F6K7J1

Conserved Domains (2) summary

cl25751
Location:284 → 372

DUF4045; Domain of unknown function (DUF4045)

cl27761
Location:43 → 294

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system