rdh8a retinol dehydrogenase 8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rdh8aprovided by ZNC
Official Full Name: retinol dehydrogenase 8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021115-3
See related: Ensembl:ENSDARG00000028048 AllianceGenome:ZFIN:ZDB-GENE-021115-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rdh8; cb501; zf1.1; zfprRDH2; zgc:73081
Summary: Predicted to enable NADP-retinol dehydrogenase activity and estradiol 17-beta-dehydrogenase activity. Predicted to act upstream of or within estrogen biosynthetic process. Predicted to be located in cytoplasm and membrane. Is expressed in several structures, including anterior axial hypoblast; epidermis; nervous system; polster; and tail bud. Orthologous to human RDH8 (retinol dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (53687640..53722316, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (53432990..53467519, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
NOT enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
NOT enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: retinol dehydrogenase 8; retinol dehydrogenase 8a

Names: zf 1.1

NP_957001.1

EC 1.1.1.300

XP_021324955.1

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200707.1 → NP_957001.1 retinol dehydrogenase 8a

See identical proteins and their annotated locations for NP_957001.1

Status: PROVISIONAL

Source sequence(s)

BC059453

UniProtKB/TrEMBL

Q6PC70

Related

ENSDARP00000032715.6, ENSDART00000032788.8

Conserved Domains (2) summary

cd09806
Location:8 → 265

type1_17beta-HSD-like_SDR_c; human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (type 1 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:8 → 207

adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

53687640..53722316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469280.1 → XP_021324955.1 retinol dehydrogenase 8 isoform X1

UniProtKB/TrEMBL

A0A8M9PV58

Conserved Domains (1) summary

cl25409
Location:8 → 211

SDR; Short-chain dehydrogenases/reductases (SDR)