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Larp7 La ribonucleoprotein 7, transcriptional regulator [ Mus musculus (house mouse) ]

Gene ID: 28036, updated on 18-Sep-2024

Summary

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Official Symbol
Larp7provided by MGI
Official Full Name
La ribonucleoprotein 7, transcriptional regulatorprovided by MGI
Primary source
MGI:MGI:107634
See related
Ensembl:ENSMUSG00000027968 AllianceGenome:MGI:107634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Wsu161e; C330027G06Rik
Summary
Enables U6 snRNA binding activity. Involved in ncRNA metabolic process; regulation of mRNA splicing, via spliceosome; and spermatogenesis. Acts upstream of or within several processes, including germ cell proliferation; negative regulation of chromatin binding activity; and positive regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; liver; sensory organ; and spleen. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 27.9), testis adult (RPKM 22.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Larp7 in Genome Data Viewer
Location:
3 G2; 3 56.54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127330363..127346998, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127536714..127553349, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ankyrin 2, brain Neighboring gene predicted gene, 52631 Neighboring gene STARR-seq mESC enhancer starr_08950 Neighboring gene predicted gene, 35535 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302b Neighboring gene microRNA 302c Neighboring gene microRNA 302a Neighboring gene microRNA 302d Neighboring gene microRNA 367 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene predicted gene, 40147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway. Li N, et al. Allergol Immunopathol (Madr), 2023. PMID 36617833
  2. LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28. Liang X, et al. Circ Res, 2021 Oct 15. PMID 34503347
  3. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Alazami AM, et al. Hum Mutat, 2012 Oct. PMID 22865833
  4. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Dai Q, et al. Cell Rep, 2014 May 8. PMID 24768001
  5. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Zhang F, et al. Cell Rep, 2020 Jul 28. PMID 32726637

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LARP7 overexpression alleviates aortic senescence and atherosclerosis.
    Title: LARP7 overexpression alleviates aortic senescence and atherosclerosis.
  2. LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
    Title: LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
  3. LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-kappaB signaling pathway.
    Title: LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway.
  4. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
    Title: LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
  5. LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28.
    Title: LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28.
  6. LARP7 regulates U6 2'-O-methylation in male germ cells which is required for splicing fidelity and spermatogenesis in mice.
    Title: LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
  7. LARP7 interacts with TUT1 nucleotidyl transferase to regulate Lin28 expression.
    Title: Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables 7SK snRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables U6 snRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in U6 2'-O-snRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in U6 2'-O-snRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in box C/D sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in box C/D sno(s)RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to Cajal body ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to Cajal body ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of snRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of 7SK snRNP ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
la-related protein 7
Names
La ribonucleoprotein domain family, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138593.2 → NP_613059.2  la-related protein 7

    See identical proteins and their annotated locations for NP_613059.2

    Status: VALIDATED

    Source sequence(s)
    AK082815, AK162147, BM946683, BU701061, BY269910
    Consensus CDS
    CCDS38626.1
    UniProtKB/Swiss-Prot
    Q05CL8, Q3TSC2, Q8K2Y6, Q8VDW3, Q9CSI2, Q9CSI9, Q9CUQ5
    UniProtKB/TrEMBL
    I3PQW3
    Related
    ENSMUSP00000029588.6, ENSMUST00000029588.10
    Conserved Domains (3) summary
    cd08032
    Location:25 → 105
    LARP_7; La RNA-binding domain of La-related protein 7
    cd12290
    Location:120 → 199
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:442 → 540
    RRM_3; RNA binding motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127330363..127346998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05CL8.2 GenPept UniProtKB/Swiss-Prot:Q05CL8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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