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F fusion glycoprotein precursor [ Human metapneumovirus ]

Gene ID: 2799939, discontinued on 26-Aug-2018
  • This record was discontinued.

Summary

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Gene symbol
F
Gene description
fusion glycoprotein precursor
Locus tag
HmVgp4
Gene type
protein coding
RNA name
fusion glycoprotein precursor
RefSeq status
PROVISIONAL
Organism
Human metapneumovirus (isolate: CAN97-83)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Pneumoviridae; Metapneumovirus
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004148.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggests that the G protein plays a central role in virus-like particle formation, and that the G protein may also play a role in the recruitment of the F and M proteins to sites of virus particle formation during virus infection.
    Title: Evidence for the interaction of the human metapneumovirus G and F proteins during virus-like particle formation.
  2. RGD(331) motif of F proteins are essential for human metapneumovirus cell-cell fusion.
    Title: Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis.
  3. human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins
    Title: The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins.
  4. Loss of charge at residues E51, D54, and E56 altered local folding and overall stability of the F protein, with dramatic consequences for fusion activity.
    Title: Potential electrostatic interactions in multiple regions affect human metapneumovirus F-mediated membrane fusion.
  5. Heparan sulfate is important for HMPV F-dependent virus-cell binding.
    Title: Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate.
  6. N-linked glycosylation of the fusion protein affect virus replication.
    Title: Effects of N-linked glycosylation of the fusion protein on replication of human metapneumovirus in vitro and in mouse lungs.
  7. report on the genetic variability of G and F gene of hMPV strains from India which clearly shows that the G protein of hMPV is continuously evolving
    Title: Genetic variability of attachment (G) and Fusion (F) protein genes of human metapneumovirus strains circulating during 2006-2009 in Kolkata, Eastern India.
  8. F protein remains highly conserved over decades.
    Title: Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years.
  9. The average interpatient sequence diversity of F gene was 1.68% and 1.64% at nucleotide and amino acid levels, respectively.
    Title: Limited inter- and intra-patient sequence diversity of the genetic lineage A human metapneumovirus fusion gene.
  10. Antibody neutralizing epitopes identified on F protein.
    Title: Identification of antibody neutralization epitopes on the fusion protein of human metapneumovirus.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General protein information

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Preferred Names
fusion glycoprotein precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004148.2 Reference assembly

    Range
    3054..4697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_012608.1 fusion glycoprotein precursor [Human metapneumovirus]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version

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