GLP1R glucagon like peptide 1 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLP1Rprovided by HGNC
Official Full Name: glucagon like peptide 1 receptorprovided by HGNC
Primary source: HGNC:HGNC:4324
See related: Ensembl:ENSG00000112164 MIM:138032; AllianceGenome:HGNC:4324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLP-1; GLP-1R; GLP-1-R
Summary: This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Expression: Biased expression in heart (RPKM 1.0), brain (RPKM 1.0) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (39048781..39091303)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (38873166..38915730)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (39016557..39059079)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucagon-like-peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association.
Title: Glucagon-like-peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association.
Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.
Title: Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.
Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts.
Title: Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts.
The role of G protein-coupled receptor kinases in GLP-1R beta-arrestin recruitment and internalisation.
Title: The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.
A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.
Title: A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.
Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity.
Title: Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity.
Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans.
Title: Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans.
[Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
Title: [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Title: Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Polymorphisms in the glucagon-like peptide-1 receptor gene and their interactions on the risk of osteoporosis in postmenopausal Chinese women.
Title: Polymorphisms in the glucagon-like peptide-1 receptor gene and their interactions on the risk of osteoporosis in postmenopausal Chinese women.

Submit: New GeneRIF Correction See all GeneRIFs (223)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH37424 (e-PCR)
- UniSTS:59655

RH46831 (e-PCR)
- UniSTS:44060

GDB:460430 (e-PCR)
- UniSTS:157487

G15954 (e-PCR)
- UniSTS:18480

SGC35239 (e-PCR)
- UniSTS:66139

Glp1r (e-PCR), detects polymorphism
- UniSTS:462685

GDB:383796 (e-PCR)
- UniSTS:157078

D6S973 (e-PCR), detects polymorphism
- UniSTS:149407

NoName (e-PCR)
- UniSTS:485811

NoName (e-PCR)
- UniSTS:480732

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon-like peptide 1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon-like peptide 1 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in response to psychosocial stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glucagon-like peptide 1 receptor

Names: GLP-1 receptor; GLP1 receptor; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002062.5 → NP_002053.3 glucagon-like peptide 1 receptor precursor

See identical proteins and their annotated locations for NP_002053.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.

Source sequence(s)

AL035690, BC113493, CK819862, KR138540

Consensus CDS

CCDS4839.1

UniProtKB/Swiss-Prot

P43220, Q2M229, Q99669

UniProtKB/TrEMBL

A0A142FHB8

Related

ENSP00000362353.4, ENST00000373256.5

Conserved Domains (2) summary

pfam00002
Location:144 → 398

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:60 → 128

HRM; Hormone receptor domain

RNA

NR_136562.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) splices out a segment of the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL035690, BC113493, CK819862, KR138540, U10037
NR_136563.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) splices out a segment of the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL035690, BC113493, CK819862, KR138540, U01156