VMA9 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: VMA9
Primary source: SGD:S000028508
Locus tag: YCL005W-A
See related: AllianceGenome:SGD:S000028508; FungiDB:YCL005W-A; VEuPathDB:YCL005W-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CWH36; LDB10
Summary: Enables ATPase-coupled ion transmembrane transporter activity. Involved in several processes, including cell wall mannoprotein biosynthetic process; cellular protein-containing complex assembly; and vacuolar acidification. Located in fungal-type vacuole membrane. Part of vacuolar proton-transporting V-type ATPase, V0 domain. Orthologous to human ATP6V0E1 (ATPase H+ transporting V0 subunit e1) and ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase-coupled ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell wall mannoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IMP Inferred from Mutant Phenotype more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_958835.1

Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis

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