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MORC1 MORC family CW-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 27136, updated on 14-Nov-2024

Summary

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Official Symbol
MORC1provided by HGNC
Official Full Name
MORC family CW-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:7198
See related
Ensembl:ENSG00000114487 MIM:603205; AllianceGenome:HGNC:7198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT33; MORC; ZCW6
Summary
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Expression
Restricted expression toward testis (RPKM 9.4) See more
Orthologs
mouse all
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Genomic context

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See MORC1 in Genome Data Viewer
Location:
3q13.13
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108958248..109118134, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111678481..111838414, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108677095..108836981, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene guanylate cyclase activator 1C Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20223 Neighboring gene MORC1 antisense RNA 1 Neighboring gene chromosome 3 open reading frame 85 Neighboring gene long intergenic non-protein coding RNA 488

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex. Mundorf A, et al. J Affect Disord, 2021 Mar 1. PMID 33401128
  2. Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms. Thomas M, et al. J Psychiatr Res, 2020 Jan. PMID 31683097, Free PMC Article
  3. Methylation of MORC1: A possible biomarker for depression? Mundorf A, et al. J Psychiatr Res, 2018 Aug. PMID 29890506
  4. MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD. Nieratschker V, et al. Transl Psychiatry, 2014 Aug 26. PMID 25158004, Free PMC Article
  5. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. Inoue N, et al. Hum Mol Genet, 1999 Jul. PMID 10369865

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex.
    Title: MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex.
  2. Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.
    Title: Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.
  3. The results of this study showed that DNA methylation in the MORC1 promoter region significantly correlates with the Beck Depression Inventory score in the examined non-clinical population.
    Title: Methylation of MORC1: A possible biomarker for depression?
  4. MORC1 is thus the first identified epigenetic marker of ELS to be present in blood cell progenitors at birth and in the brain in adulthood.
    Title: MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic programing of male pronucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in retrotransposition IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transposable element silencing by heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MORC family CW-type zinc finger protein 1
Names
cancer/testis antigen 33
microrchidia, mouse, homolog of

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014429.4 → NP_055244.3  MORC family CW-type zinc finger protein 1

    See identical proteins and their annotated locations for NP_055244.3

    Status: REVIEWED

    Source sequence(s)
    AC016948, AC112138, BC050307
    Consensus CDS
    CCDS2955.1
    UniProtKB/Swiss-Prot
    B4DYX1, E7ERX1, Q7L8E2, Q86VD1, Q9NSG7, Q9Y6D4
    Related
    ENSP00000232603.5, ENST00000232603.10
    Conserved Domains (3) summary
    pfam07496
    Location:482 → 527
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28 → 160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293 → 373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108958248..109118134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247362.3 → XP_005247419.1  MORC family CW-type zinc finger protein 1 isoform X2

    Conserved Domains (3) summary
    pfam07496
    Location:512 → 557
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28 → 160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293 → 373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  2. XM_047447968.1 → XP_047303924.1  MORC family CW-type zinc finger protein 1 isoform X6

  3. XM_011512692.2 → XP_011510994.1  MORC family CW-type zinc finger protein 1 isoform X3

    Conserved Domains (3) summary
    pfam07496
    Location:484 → 529
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28 → 160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295 → 375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  4. XM_011512693.2 → XP_011510995.1  MORC family CW-type zinc finger protein 1 isoform X5

    Conserved Domains (3) summary
    pfam07496
    Location:514 → 559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28 → 160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295 → 375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  5. XM_011512691.2 → XP_011510993.1  MORC family CW-type zinc finger protein 1 isoform X1

    Conserved Domains (3) summary
    pfam07496
    Location:514 → 559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28 → 160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295 → 375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  6. XM_011512694.1 → XP_011510996.1  MORC family CW-type zinc finger protein 1 isoform X7

    Conserved Domains (1) summary
    pfam07496
    Location:415 → 460
    zf-CW; CW-type Zinc Finger

  7. XM_011512696.2 → XP_011510998.1  MORC family CW-type zinc finger protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011510998.1

    Conserved Domains (2) summary
    pfam07496
    Location:288 → 333
    zf-CW; CW-type Zinc Finger
    cl23750
    Location:69 → 149
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  8. XM_047447970.1 → XP_047303926.1  MORC family CW-type zinc finger protein 1 isoform X10

  9. XM_011512697.3 → XP_011510999.1  MORC family CW-type zinc finger protein 1 isoform X9

    Conserved Domains (1) summary
    pfam07496
    Location:263 → 308
    zf-CW; CW-type Zinc Finger

  10. XM_017006169.3 → XP_016861658.1  MORC family CW-type zinc finger protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111678481..111838414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346172.1 → XP_054202147.1  MORC family CW-type zinc finger protein 1 isoform X2

  2. XM_054346175.1 → XP_054202150.1  MORC family CW-type zinc finger protein 1 isoform X6

  3. XM_054346173.1 → XP_054202148.1  MORC family CW-type zinc finger protein 1 isoform X3

  4. XM_054346174.1 → XP_054202149.1  MORC family CW-type zinc finger protein 1 isoform X5

  5. XM_054346171.1 → XP_054202146.1  MORC family CW-type zinc finger protein 1 isoform X1

  6. XM_054346176.1 → XP_054202151.1  MORC family CW-type zinc finger protein 1 isoform X7

  7. XM_054346178.1 → XP_054202153.1  MORC family CW-type zinc finger protein 1 isoform X8

  8. XM_054346177.1 → XP_054202152.1  MORC family CW-type zinc finger protein 1 isoform X8

  9. XM_054346180.1 → XP_054202155.1  MORC family CW-type zinc finger protein 1 isoform X10

  10. XM_054346179.1 → XP_054202154.1  MORC family CW-type zinc finger protein 1 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VD1.2 GenPept UniProtKB/Swiss-Prot:Q86VD1

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