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PF3D7_0731500 erythrocyte binding antigen-175 [ Plasmodium falciparum 3D7 ]

Gene ID: 2654998, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0731500
Gene description
erythrocyte binding antigen-175
Locus tag
PF3D7_0731500
See related
PlasmoDB:PF3D7_0731500; VEuPathDB:PF3D7_0731500
Gene type
protein coding
RNA name
erythrocyte binding antigen-175
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0731500 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
4
Sequence:
Chromosome: 7; NC_004328.3 (1358055..1362929)

Chromosome 7 - NC_004328.3Genomic Context describing neighboring genes Neighboring gene Plasmodium exported protein (PHISTb), unknown function Neighboring gene pseudo Neighboring gene acyl-CoA synthetase Neighboring gene Plasmodium exported protein (hyp9), unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004328.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Designing peptide-based vaccine candidates for Plasmodium falciparum erythrocyte binding antigen 175. Chauhan S, et al. Biologicals, 2020 Sep. PMID 32718776
  2. Genetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum. Yasukochi Y, et al. Malar J, 2015 Aug 1. PMID 26231699, Free PMC Article
  3. Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175. Chen E, et al. PLoS Pathog, 2013. PMID 23717209, Free PMC Article
  4. The upstream sequence segment of the C-terminal cysteine-rich domain is required for microneme trafficking of Plasmodium falciparum erythrocyte binding antigen 175. Sakura T, et al. Parasitol Int, 2013 Apr. PMID 23268338
  5. Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies. Sim BK, et al. PLoS One, 2011 Apr 14. PMID 21533224, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Designing peptide-based vaccine candidates for Plasmodium falciparum erythrocyte binding antigen 175.
    Title: Designing peptide-based vaccine candidates for Plasmodium falciparum erythrocyte binding antigen 175.
  2. The authors show that Plasmodium falciparum EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin A and activating a phosphorylation cascade that includes erythrocyte cytoskeletal proteins resulting in changes in the viscoelastic properties of the host cell.
    Title: Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.
  3. Clinical falciparum malaria isolates from Thailand were used to study the genetic variation of EBA-175 in P. falciparum through dispersal of humans out of Africa.
    Title: Genetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum.
  4. PfEBA-175 engages multiple glycans of GpA encoded by exon 3 and that the presentation of glycans is likely required for high-avidity binding.
    Title: Critical glycosylated residues in exon three of erythrocyte glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity.
  5. These data demonstrate the importance of PfEBA175 regions other than the DBL domains in the interaction with GYPA and merit their inclusion in an EBA175-based vaccine.
    Title: Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design.
  6. Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175.
    Title: Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175.
  7. stage specific expression of EBA-175 showed that the primary focus of activity was the merozoite stage. A recombinant RII protein vaccine consisting of both F1 and F2 domains
    Title: Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies.
  8. EBA-175, MSP-3 and AMA-1 from isolates from countries in central and west Africa were assessed for allelic diversity; detected a clinical increase in eba 175 F-allele frequency from west to east across the study region
    Title: Genetic diversity of polymorphic vaccine candidate antigens (apical membrane antigen-1, merozoite surface protein-3, and erythrocyte binding antigen-175) in Plasmodium falciparum isolates from western and central Africa.
  9. erythrocyte-binding antigen 175 gene polymorphisms are associated with severe malaria.
    Title: Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria.
  10. Interleukin-21 is associated with IgG1 and IgG3 antibodies to erythrocyte-binding antigen-175 peptide 4 of Plasmodium falciparum in Gabonese children with acute falciparum malaria
    Title: Interleukin-21 is associated with IgG1 and IgG3 antibodies to erythrocyte-binding antigen-175 peptide 4 of Plasmodium falciparum in Gabonese children with acute falciparum malaria.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables host cell surface receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within symbiont entry into host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within symbiont-mediated perturbation of host receptor-mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular vesicle HDA PubMed 
located_in microneme IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
erythrocyte binding antigen-175

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004328.3 Reference assembly

    Range
    1358055..1362929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349171.2 → XP_001349207.2  erythrocyte binding antigen-175 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349207.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V933, Q8IBE8, W7JEH3, W7JW35
    Conserved Domains (4) summary
    PTZ00176
    Location:172 → 695
    PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
    PTZ00121
    Location:1082 → 1494
    PTZ00121; MAEBL; Provisional
    COG5271
    Location:923 → 1179
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam11556
    Location:1335 → 1415
    EBA-175_VI; Erythrocyte binding antigen 175
Nucleotide Protein
Heading Accession and Version

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