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Unc-115a Uncoordinated 115a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 261629, updated on 22-Aug-2024

Summary

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Official Symbol
Unc-115aprovided by FlyBase
Official Full Name
Uncoordinated 115aprovided by FlyBase
Primary source
FLYBASE:FBgn0051352
Locus tag
Dmel_CG31352
See related
AllianceGenome:FB:FBgn0051352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.21; CG31352; CG9489; Dmel\CG31352; dunc-115; Dunc-115; unc-115; unc-15a
Summary
Predicted to enable actin filament binding activity. Involved in photoreceptor cell axon guidance. Located in nucleoplasm. Is expressed in several structures, including adult brain; circulatory system; embryonic/larval digestive system; extended germ band embryo; and presumptive embryonic/larval system. Orthologous to several human genes including ABLIM1 (actin binding LIM protein 1) and ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
85E4-85E5; 3-49 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9694386..9705417, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5520108..5531139, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 115b Neighboring gene p24-related-2 Neighboring gene uncharacterized protein Neighboring gene trabid Neighboring gene small Cajal body-specific RNA : PsiU1-6 Neighboring gene dalmatian

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Analysis of Actin-Binding Proteins in the Central Nervous System of Drosophila. He Q, et al. Methods Mol Biol, 2022. PMID 34542862
  2. Drosophila Dunc-115 mediates axon projection through actin binding. Roblodowski C, et al. Invert Neurosci, 2017 Mar. PMID 28124181
  3. Role of Drosophila gene dunc-115 in nervous system. Garcia MC, et al. Invert Neurosci, 2007 Jun. PMID 17505850
  4. Precise maps of RNA polymerase reveal how promoters direct initiation and pausing. Kwak H, et al. Science, 2013 Feb 22. PMID 23430654, Free PMC Article
  5. Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche. Ke YT, et al. G3 (Bethesda), 2019 Jun 5. PMID 31018943, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm HDA PubMed 

General protein information

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Preferred Names
uncoordinated 115a
Names
CG31352-PA
CG31352-PB
CG31352-PC
CG31352-PE
CG31352-PF
CG31352-PG
CG31352-PH
CG31352-PJ
Unc-115a-PA
Unc-115a-PB
Unc-115a-PC
Unc-115a-PE
Unc-115a-PF
Unc-115a-PG
Unc-115a-PH
Unc-115a-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9694386..9705417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300328.1 → NP_001287257.1  uncoordinated 115a, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287257.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGZ0, E8NH19
    Conserved Domains (6) summary
    cd09327
    Location:8 → 59
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:64 → 119
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:173 → 224
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:232 → 288
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:753 → 787
    VHP; Villin headpiece domain
    pfam16182
    Location:726 → 751
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. NM_001300329.1 → NP_001287258.1  uncoordinated 115a, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287258.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LI11, E8NH01
    Conserved Domains (6) summary
    cd09327
    Location:46 → 97
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:102 → 157
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:211 → 262
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:270 → 326
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:791 → 825
    VHP; Villin headpiece domain
    pfam16182
    Location:764 → 789
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. NM_001170102.2 → NP_001163573.1  uncoordinated 115a, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIH3, E8NH01
    Conserved Domains (6) summary
    cd09327
    Location:46 → 97
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:102 → 157
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:211 → 262
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:270 → 326
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:810 → 844
    VHP; Villin headpiece domain
    pfam16182
    Location:783 → 808
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  4. NM_001300330.1 → NP_001287259.1  uncoordinated 115a, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGY1, C4IY10
    Conserved Domains (6) summary
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:195 → 246
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:254 → 310
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:794 → 828
    VHP; Villin headpiece domain
    pfam16182
    Location:767 → 792
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  5. NM_001300331.1 → NP_001287260.1  uncoordinated 115a, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGY0, C4IY10
    Conserved Domains (6) summary
    cd09327
    Location:8 → 59
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:64 → 119
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:173 → 224
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:232 → 288
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:738 → 772
    VHP; Villin headpiece domain
    pfam16182
    Location:711 → 736
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  6. NM_001170104.3 → NP_001163575.2  uncoordinated 115a, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY10, E1JIH1
    Conserved Domains (6) summary
    cd09327
    Location:8 → 59
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:64 → 119
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:173 → 224
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:232 → 288
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:779 → 813
    VHP; Villin headpiece domain
    pfam16182
    Location:752 → 777
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  7. NM_141673.6 → NP_649930.4  uncoordinated 115a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649930.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY10, Q95V20, Q9VH91
    Related
    FBpp0081570
    Conserved Domains (6) summary
    cd09327
    Location:8 → 59
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:64 → 119
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:173 → 224
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:232 → 288
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:772 → 806
    VHP; Villin headpiece domain
    pfam16182
    Location:745 → 770
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  8. NM_001170103.2 → NP_001163574.1  uncoordinated 115a, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIH2, E8NH19
    Conserved Domains (6) summary
    cd09327
    Location:41 → 92
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:97 → 152
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:206 → 257
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:265 → 321
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:805 → 839
    VHP; Villin headpiece domain
    pfam16182
    Location:778 → 803
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGY0 A0A0B4LGY0
A0A0B4LGY1 A0A0B4LGY1
A0A0B4LGZ0 A0A0B4LGZ0
A0A0B4LI11 A0A0B4LI11
E1JIH1 E1JIH1
E1JIH2 E1JIH2
E1JIH3 E1JIH3
Q9VH91 Q9VH91

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