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DNM3 dynamin 3 [ Homo sapiens (human) ]

Gene ID: 26052, updated on 14-Nov-2024

Summary

Official Symbol
DNM3provided by HGNC
Official Full Name
dynamin 3provided by HGNC
Primary source
HGNC:HGNC:29125
See related
Ensembl:ENSG00000197959 MIM:611445; AllianceGenome:HGNC:29125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dyna III
Summary
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Biased expression in brain (RPKM 10.0), adrenal (RPKM 2.5) and 8 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See DNM3 in Genome Data Viewer
Location:
1q24.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (171841498..172418466)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (171198091..171775179)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171810638..172387606)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:171786162-171787148 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:171787149-171788134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2086 Neighboring gene ribosomal protein S15 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:171840934-171841454 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2087 Neighboring gene DNM3 intronic transcript 1 Neighboring gene MPRA-validated peak455 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:171911601-171912102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:171935008-171935684 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:171935685-171936361 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:171952925-171953114 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:172025253-172025838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2088 Neighboring gene microRNA 199a-2 Neighboring gene microRNA 3120 Neighboring gene DNM3 opposite strand/antisense RNA Neighboring gene microRNA 214 Neighboring gene MPRA-validated peak456 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:172247487-172248141 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:172300102-172300228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2090 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:172329514-172330140 Neighboring gene uncharacterized LOC102724528 Neighboring gene RNA, U6 small nuclear 157, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:172397968-172398490 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:172413041-172413564 Neighboring gene chromosome 1 open reading frame 105 Neighboring gene Sharpr-MPRA regulatory region 10840 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:172466106-172466606 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:172466607-172467107 Neighboring gene Sharpr-MPRA regulatory region 5023 Neighboring gene Sharpr-MPRA regulatory region 3225 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2094 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:172539927-172540926 Neighboring gene SUN domain containing ossification factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
EBI GWAS Catalog
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DNM3 by shRNA significantly inhibits HIV-1 replication in CD4+ T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0820, MGC70433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nitric-oxide synthase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of postsynapse IEA
Inferred from Electronic Annotation
more info
 
enables type 1 metabotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables type 5 metabotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of apical tubulobulbar complex IEA
Inferred from Electronic Annotation
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
part_of basal tubulobulbar complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine head IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic endocytic zone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic cleft IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynamin-3
Names
T-dynamin
dynamin family member
dynamin, testicular
NP_001129599.1
NP_001265181.1
NP_001337133.1
NP_001337134.1
NP_001337135.1
NP_056384.2
XP_005245136.1
XP_016856465.1
XP_016856466.1
XP_016856467.1
XP_016856468.1
XP_016856469.1
XP_016856471.1
XP_016856473.1
XP_016856474.1
XP_016856475.1
XP_016856477.1
XP_016856478.1
XP_016856480.1
XP_016856481.1
XP_047273345.1
XP_047273351.1
XP_047273355.1
XP_047273365.1
XP_047273373.1
XP_054191855.1
XP_054191856.1
XP_054191857.1
XP_054191858.1
XP_054191859.1
XP_054191860.1
XP_054191861.1
XP_054191862.1
XP_054191863.1
XP_054191864.1
XP_054191865.1
XP_054191866.1
XP_054191867.1
XP_054191868.1
XP_054191869.1
XP_054191870.1
XP_054191871.1
XP_054191872.1
XP_054191873.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136127.3NP_001129599.1  dynamin-3 isoform b

    See identical proteins and their annotated locations for NP_001129599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB020627, AL035110, AL136712, BC037326, DC334207, Z97195
    Consensus CDS
    CCDS44276.1
    UniProtKB/Swiss-Prot
    Q9UQ16
    Related
    ENSP00000356705.1, ENST00000367731.5
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79728
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
    cl22974
    Location:762822
    HpaP; Type III secretion protein (HpaP)
  2. NM_001278252.2NP_001265181.1  dynamin-3 isoform c

    See identical proteins and their annotated locations for NP_001265181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC064546, DC334207
    Consensus CDS
    CCDS60356.1
    UniProtKB/TrEMBL
    B3KPF2
    Related
    ENSP00000356707.2, ENST00000367733.6
    Conserved Domains (3) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216501
    Dynamin_M; Dynamin central region
    cl17171
    Location:514553
    PH-like; Pleckstrin homology-like domain
  3. NM_001350204.2NP_001337133.1  dynamin-3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AB020627, AL035110, AL136712, AL512843, BC037326, DC334207, Z97195
    Consensus CDS
    CCDS86032.1
    UniProtKB/Swiss-Prot
    A9Z1Y1, O14982, O95555, Q1MTM8, Q5W129, Q6P2G1, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6, Q9UQ16
    Related
    ENSP00000347457.5, ENST00000355305.9
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
    cl26464
    Location:754841
    Atrophin-1; Atrophin-1 family
  4. NM_001350205.2NP_001337134.1  dynamin-3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL512843, BC064546, DC334207
    UniProtKB/TrEMBL
    B3KPF2
    Conserved Domains (3) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216501
    Dynamin_M; Dynamin central region
    cl17171
    Location:526563
    PH-like; Pleckstrin homology-like domain
  5. NM_001350206.2NP_001337135.1  dynamin-3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AB020627, AL035110, AL512843, CA445187, DC334207
    Consensus CDS
    CCDS91107.1
    UniProtKB/TrEMBL
    H0YBC6
    Related
    ENSP00000429165.2, ENST00000485254.3
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
    cl26464
    Location:754838
    Atrophin-1; Atrophin-1 family
  6. NM_015569.5NP_056384.2  dynamin-3 isoform a

    See identical proteins and their annotated locations for NP_056384.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB020627, AL035110, AL136712, BC037326, DC334207, Z97195
    Consensus CDS
    CCDS53431.1
    UniProtKB/Swiss-Prot
    Q9UQ16
    Related
    ENSP00000486701.1, ENST00000627582.3
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79732
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651739
    GED; Dynamin GTPase effector domain
    cl22974
    Location:766826
    HpaP; Type III secretion protein (HpaP)

RNA

  1. NR_146559.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB020627, AL035110, AL136712, AL512843, BC037326, DC334207, Z97195

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    171841498..172418466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000979.2XP_016856468.1  dynamin-3 isoform X4

  2. XM_017000984.2XP_016856473.1  dynamin-3 isoform X8

  3. XM_047417389.1XP_047273345.1  dynamin-3 isoform X10

  4. XM_017000976.2XP_016856465.1  dynamin-3 isoform X1

  5. XM_017000977.2XP_016856466.1  dynamin-3 isoform X2

  6. XM_005245079.2XP_005245136.1  dynamin-3 isoform X6

    UniProtKB/Swiss-Prot
    Q9UQ16
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79742
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661749
    GED; Dynamin GTPase effector domain
    cl22974
    Location:776836
    HpaP; Type III secretion protein (HpaP)
  7. XM_017000982.3XP_016856471.1  dynamin-3 isoform X7

  8. XM_017000978.2XP_016856467.1  dynamin-3 isoform X3

  9. XM_017000985.2XP_016856474.1  dynamin-3 isoform X9

  10. XM_047417399.1XP_047273355.1  dynamin-3 isoform X14

  11. XM_047417417.1XP_047273373.1  dynamin-3 isoform X17

    Related
    ENSP00000429701.1, ENST00000520906.5
  12. XM_017000991.2XP_016856480.1  dynamin-3 isoform X16

    UniProtKB/TrEMBL
    B3KPF2
    Conserved Domains (3) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79500
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
  13. XM_017000989.2XP_016856478.1  dynamin-3 isoform X15

    UniProtKB/TrEMBL
    B3KPF2
  14. XM_017000988.2XP_016856477.1  dynamin-3 isoform X12

    UniProtKB/TrEMBL
    B3KPF2
  15. XM_047417395.1XP_047273351.1  dynamin-3 isoform X13

  16. XM_047417409.1XP_047273365.1  dynamin-3 isoform X16

  17. XM_017000992.2XP_016856481.1  dynamin-3 isoform X18

    UniProtKB/TrEMBL
    B3KPF2
  18. XM_017000980.2XP_016856469.1  dynamin-3 isoform X5

  19. XM_017000986.2XP_016856475.1  dynamin-3 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    171198091..171775179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335883.1XP_054191858.1  dynamin-3 isoform X4

  2. XM_054335889.1XP_054191864.1  dynamin-3 isoform X10

  3. XM_054335887.1XP_054191862.1  dynamin-3 isoform X8

  4. XM_054335880.1XP_054191855.1  dynamin-3 isoform X1

  5. XM_054335881.1XP_054191856.1  dynamin-3 isoform X2

  6. XM_054335885.1XP_054191860.1  dynamin-3 isoform X6

  7. XM_054335882.1XP_054191857.1  dynamin-3 isoform X3

  8. XM_054335886.1XP_054191861.1  dynamin-3 isoform X7

  9. XM_054335888.1XP_054191863.1  dynamin-3 isoform X9

  10. XM_054335893.1XP_054191868.1  dynamin-3 isoform X14

  11. XM_054335897.1XP_054191872.1  dynamin-3 isoform X17

  12. XM_054335896.1XP_054191871.1  dynamin-3 isoform X16

  13. XM_054335894.1XP_054191869.1  dynamin-3 isoform X15

  14. XM_054335891.1XP_054191866.1  dynamin-3 isoform X12

  15. XM_054335892.1XP_054191867.1  dynamin-3 isoform X13

  16. XM_054335895.1XP_054191870.1  dynamin-3 isoform X16

  17. XM_054335898.1XP_054191873.1  dynamin-3 isoform X18

  18. XM_054335884.1XP_054191859.1  dynamin-3 isoform X5

  19. XM_054335890.1XP_054191865.1  dynamin-3 isoform X11