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F35A5.1 Titin-like [ Caenorhabditis elegans ]

Gene ID: 259699, updated on 2-Nov-2024

Summary

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Official Symbol
F35A5.1
Official Full Name
Titin-like
Primary source
WormBase:WBGene00018024
Locus tag
CELE_F35A5.1
See related
AllianceGenome:WB:WBGene00018024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament bundle assembly. Predicted to be located in neurofilament. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F35A5.1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (3807466..3816429)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1 Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Forkhead transcription factor fkh-9 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon development IEA
Inferred from Electronic Annotation
more info
  
involved_in intermediate filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in neurofilament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Titin-like
NP_508662.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3807466..3816429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076261.7 → NP_508662.4  Titin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508662.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SGM2, Q20007
    Conserved Domains (1) summary
    PHA03247
    Location:447 → 910
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
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