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TAS2R45 taste 2 receptor member 45 [ Homo sapiens (human) ]

Gene ID: 259291, updated on 2-Nov-2024

Summary

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Official Symbol
TAS2R45provided by HGNC
Official Full Name
taste 2 receptor member 45provided by HGNC
Primary source
HGNC:HGNC:18876
See related
MIM:613967; AllianceGenome:HGNC:18876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR59; T2R45; ZG24P
Summary
Predicted to enable G protein-coupled receptor activity and bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
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Genomic context

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See TAS2R45 in Genome Data Viewer
Location:
12p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 (ALT_REF_LOCI_2) NT_187658.1 (291887..292786, complement)
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 (ALT_REF_LOCI_1) NW_003571050.1 (327525..328424, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10966219..10967118, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 (PATCHES) NW_003571050.1 (327525..328424, complement)

NW_003571050.1Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 43 Neighboring gene taste 2 receptor member 68 pseudogene Neighboring gene taste 2 receptor member 30 Neighboring gene taste 2 receptor member 18 pseudogene

NT_187658.1Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 46 Neighboring gene taste 2 receptor member 68 pseudogene Neighboring gene taste 2 receptor member 30 Neighboring gene small integral membrane protein 10 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
  2. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
  3. The molecular receptive ranges of human TAS2R bitter taste receptors. Meyerhof W, et al. Chem Senses, 2010 Feb. PMID 20022913
  4. Receptors for bitter and sweet taste. Montmayeur JP, et al. Curr Opin Neurobiol, 2002 Aug. PMID 12139982
  5. Molecular mechanisms of bitter and sweet taste transduction. Margolskee RF. J Biol Chem, 2002 Jan 4. PMID 11696554

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • MGC119923, MGC119924, MGC119925

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
taste receptor type 2 member 45
Names
G-protein coupled receptor 59
taste receptor, type 2, member 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176886.2 → NP_795367.2  taste receptor type 2 member 45

    See identical proteins and their annotated locations for NP_795367.2

    Status: VALIDATED

    Source sequence(s)
    AC217021
    UniProtKB/Swiss-Prot
    P59539
    UniProtKB/TrEMBL
    A0A0J9YXD8
    Conserved Domains (1) summary
    pfam05296
    Location:1 → 298
    TAS2R; Taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    327525..328424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    291887..292786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10966219..10967118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59539.1 GenPept UniProtKB/Swiss-Prot:P59539

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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