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Msi1 musashi RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259272, updated on 10-Oct-2024

Summary

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Official Symbol
Msi1provided by RGD
Official Full Name
musashi RNA-binding protein 1provided by RGD
Primary source
RGD:628778
See related
EnsemblRapid:ENSRNOG00000001156 AllianceGenome:RGD:628778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msi1h
Summary
Predicted to enable identical protein binding activity and poly(U) RNA binding activity. Involved in epithelial cell differentiation and response to hormone. Predicted to be located in nucleus. Predicted to be part of polysome. Predicted to be active in cytoplasm. Biomarker of brain infarction and brain ischemia. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 48.8), Adrenal (RPKM 47.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Msi1 in Genome Data Viewer
Location:
12q16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46815225..46911852, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41158301..41251134, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46899835..46935335, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene sirtuin 4 Neighboring gene phospholipase A2 group IB Neighboring gene uncharacterized LOC134481302 Neighboring gene uncharacterized LOC102547958 Neighboring gene transmembrane protein 258, pseudogene 2 Neighboring gene cytochrome c oxidase subunit 6A1 Neighboring gene TP53 regulated inhibitor of apoptosis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Musashi-1 Increases in Bone Healing. Padial-Molina M, et al. Int J Mol Sci, 2021 Mar 26. PMID 33810326, Free PMC Article
  2. Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution. Nagata H, et al. FEBS Lett, 2006 Jan 9. PMID 16360154
  3. Proliferation and differentiation of neural stem cells in adult rats after cerebral infarction. Zhang B, et al. Chin Med Sci J, 2004 Jun. PMID 15250238
  4. Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. Yagita Y, et al. J Neurosci Res, 2002 Sep 15. PMID 12205668
  5. Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1. Cuadrado A, et al. Mol Cell Neurosci, 2002 Jun. PMID 12093154

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
    Title: Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
  2. Expression of Musashi-1 Increases in Bone Healing.
    Title: Expression of Musashi-1 Increases in Bone Healing.
  3. data suggest that in response to environmental cues that oppose cell cycle progression, regulation of Musashi function is required to promote target mRNA translation and cell fate transition
    Title: Neural stem and progenitor cell fate transition requires regulation of Musashi1 function.
  4. Results do not support MSI-1 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin.
    Title: Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
  5. Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia
    Title: [Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia].
  6. neuronal progenitor cells in the SGZ expressed Msi1 but not nestin.
    Title: Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 1
Names
Musashi homolog 1(Drosophila)
musashi-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148890.2 → NP_683688.1  RNA-binding protein Musashi homolog 1

    See identical proteins and their annotated locations for NP_683688.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q8K3P4
    UniProtKB/TrEMBL
    A6J1U2, F1LRH1
    Related
    ENSRNOP00000001532.6, ENSRNOT00000001532.8
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46815225..46911852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271088.1 → XP_063127158.1  RNA-binding protein Musashi homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K3P4

  2. XM_039089125.2 → XP_038945053.1  RNA-binding protein Musashi homolog 1 isoform X7

    UniProtKB/TrEMBL
    A6J1U2, F1LRH1
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 236
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  3. XM_039089122.2 → XP_038945050.1  RNA-binding protein Musashi homolog 1 isoform X4

    UniProtKB/TrEMBL
    A6J1U2, F1LRH1
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  4. XM_039089121.2 → XP_038945049.1  RNA-binding protein Musashi homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GAA4, A6J1U2, F1LRH1
    Related
    ENSRNOP00000084373.1, ENSRNOT00000117406.3
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 320
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  5. XM_039089120.2 → XP_038945048.1  RNA-binding protein Musashi homolog 1 isoform X2

    UniProtKB/TrEMBL
    A6J1U2, F1LRH1
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 328
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  6. XM_039089123.2 → XP_038945051.1  RNA-binding protein Musashi homolog 1 isoform X5

    UniProtKB/TrEMBL
    A6J1U2, F1LRH1
    Conserved Domains (2) summary
    TIGR01628
    Location:54 → 295
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:66 → 139
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  7. XM_063271091.1 → XP_063127161.1  RNA-binding protein Musashi homolog 1 isoform X9

  8. XM_063271090.1 → XP_063127160.1  RNA-binding protein Musashi homolog 1 isoform X8

  9. XM_039089124.2 → XP_038945052.1  RNA-binding protein Musashi homolog 1 isoform X6

    Conserved Domains (2) summary
    TIGR01628
    Location:37 → 241
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:36 → 85
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_010056364.1 RNA Sequence

  2. XR_010056363.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3P4.1 GenPept UniProtKB/Swiss-Prot:Q8K3P4

Gene LinkOut

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