U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

adcyap1a adenylate cyclase activating polypeptide 1a [ Danio rerio (zebrafish) ]

Gene ID: 259257, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
adcyap1aprovided by ZNC
Official Full Name
adenylate cyclase activating polypeptide 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020809-4
See related
Ensembl:ENSDARG00000004015 AllianceGenome:ZFIN:ZDB-GENE-020809-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PACAP1; adcyap1; GHRH-LP1; GRF-PACAP; zgc:103760; ghrh-pacap1; xx:af217251
Summary
Predicted to enable neuropeptide hormone activity; peptide hormone receptor binding activity; and pituitary adenylate cyclase activating polypeptide activity. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including central nervous system; germ ring; gut; head; and male organism. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See adcyap1a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71547747..71556731)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71306606..71315590)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene alkaline ceramidase 2 Neighboring gene thymidylate synthetase Neighboring gene methyltransferase 4, N6-adenosine Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene structural maintenance of chromosomes flexible hinge domain-containing protein 1-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae. Holmberg A, et al. J Exp Biol, 2004 Nov. PMID 15498954
  2. Pituitary adenylate cyclase-activating polypeptide in the brain, spinal cord and sensory organs of the zebrafish, Danio rerio, during development. Mathieu M, et al. Brain Res Dev Brain Res, 2004 Jul 19. PMID 15246703
  3. Characterization of the gene encoding both growth hormone-releasing hormone (GRF) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish. Fradinger EA, et al. Mol Cell Endocrinol, 2000 Jul 25. PMID 10940499
  4. Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain. Nakamachi T, et al. Peptides, 2018 May. PMID 29535004
  5. Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish. Krueckl SL, et al. J Comp Neurol, 2003 Jan 13. PMID 12483690

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study reveals the distribution of immunoreactive GHRH-like peptide in structures of the zebrafish brain; results suggest involvement of GHRH-LP in both neuroendocrine and feeding-associated nervous circuits
    Title: Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio).
  2. expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development
    Title: Role of two genes encoding PACAP in early brain development in zebrafish.
  3. The temporal and spatial expression pattern of the ghrh-pacap1 transcript suggests that thise hormones may modulate patterning during development.
    Title: Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish.
  4. signal pathways, transcript distribution, and splice variants are investigated
    Title: Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pituitary adenylate cyclase activating polypeptide activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenylate cyclase activating polypeptide 1a
Names
growth hormone-releasing hormone

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328496.1 → NP_001315425.1  adenylate cyclase activating polypeptide 1a isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    FP016237
    UniProtKB/TrEMBL
    B5DDL8, F6P3I8, Q5XJ29
    Related
    ENSDARP00000008265.6, ENSDART00000012070.8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone

  2. NM_152885.2 → NP_690841.1  adenylate cyclase activating polypeptide 1a isoform 1 precursor

    See identical proteins and their annotated locations for NP_690841.1

    Status: VALIDATED

    Source sequence(s)
    FP016237
    UniProtKB/TrEMBL
    A0A8N7UZR9, Q9DE29
    Related
    ENSDARP00000145584.1, ENSDART00000180869.1
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71547747..71556731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.