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fml1 ATP-dependent 3' to 5' DNA helicase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543668, updated on 14-Nov-2024

Summary

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Official Symbol
fml1
Official Full Name
ATP-dependent 3' to 5' DNA helicase
Primary source
PomBase:SPAC9.05
Locus tag
SPOM_SPAC9.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mfh1
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Genomic context

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See fml1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (1470834..1476275)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene GTPase Rbg1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene steroid reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Sun W, et al. Mol Cell, 2008 Oct 10. PMID 18851838, Free PMC Article
  2. The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair. Nandi S, et al. Nucleic Acids Res, 2012 Oct. PMID 22844101, Free PMC Article
  3. The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. Wong IN, et al. Elife, 2019 Dec 19. PMID 31855181, Free PMC Article
  4. The fission yeast FANCM ortholog directs non-crossover recombination during meiosis. Lorenz A, et al. Science, 2012 Jun 22. PMID 22723423, Free PMC Article
  5. Regulation of mitotic recombination between DNA repeats in centromeres. Zafar F, et al. Nucleic Acids Res, 2017 Nov 2. PMID 28977643, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we confirm that Fml1 does indeed suppress IFSA, and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf2 via its C-terminal domain.
    Title: The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.
  2. Mutations that impair ATP hydrolysis of Fml1 block DNA unwinding without blocking DNA binding.
    Title: The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.
  3. findings show that Fml1, the Fanconi anemia complementation group M (FANCM)-ortholog of Schizosaccharomyces pombe, directs the formation of non-crossovers (NCOs)during meiosis in competition with the Mus81-dependent pro-crossover (CO) pathway
    Title: The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables four-way junction DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables four-way junction helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA strand displacement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Okazaki fragment processing involved in mitotic DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic strand displacement involved in double-strand break repair via SDSA IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FANCM-MHF complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleolus HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent 3' to 5' DNA helicase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1470834..1476275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018780.4 → NP_593348.2  ATP-dependent 3' to 5' DNA helicase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593348.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UT23
    Conserved Domains (4) summary
    COG1111
    Location:58 → 613
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:87 → 230
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:412 → 544
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd12091
    Location:280 → 396
    FANCM_ID; Insert domain of FANCM and related proteins
Nucleotide Protein
Heading Accession and Version

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