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hos2 class 1 histone deacetylase Hos2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543643, updated on 14-Nov-2024

Summary

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Official Symbol
hos2
Official Full Name
class 1 histone deacetylase Hos2
Primary source
PomBase:SPAC3G9.07c
Locus tag
SPOM_SPAC3G9.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
hda1; phd1
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Genomic context

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See hos2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3169671..3171512)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene translation initiation factor eIF2 alpha subunit Neighboring gene ncRNA Neighboring gene chromatin modification-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phenylalanine--tRNA (Phe) ligase alpha subunit Frs2 Neighboring gene GTPase-activating protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A. Kim YB, et al. FEBS Lett, 1998 Oct 2. PMID 9781677
  2. Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity. Bjerling P, et al. Mol Cell Biol, 2002 Apr. PMID 11884604, Free PMC Article
  3. HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress. Johnsson A, et al. EMBO Rep, 2009 Sep. PMID 19633696, Free PMC Article
  4. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. Wirén M, et al. EMBO J, 2005 Aug 17. PMID 16079916, Free PMC Article
  5. Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast. Yu Y, et al. Sci Rep, 2016 Aug 19. PMID 27538348, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H4K16 deacetylase activity, hydrolytic mechanism EXP
Inferred from Experiment
more info
 PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to transcription corepressor activity IC
Inferred by Curator
more info
  
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L-Expanded complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Set3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
NOT is_active_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
class 1 histone deacetylase Hos2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3169671..3171512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019506.3 → NP_594079.1  class 1 histone deacetylase Hos2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594079.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13298
    Conserved Domains (2) summary
    cd11598
    Location:28 → 337
    HDAC_Hos2; Class I histone deacetylases including ScHos2 and SpPhd1
    PTZ00063
    Location:25 → 426
    PTZ00063; histone deacetylase; Provisional
Nucleotide Protein
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